Fig. 1.

Schematic representation of FUBP1 protein domains with its associated mutations in leukemia identified so far. FUBP1 encompasses three domains, one inhibitory domain in N-terminal, one central domain containing four KH subdomains for DNA and RNA bindings and one transactivation domain in C-terminal. Few somatic mutations of FUBP1 have been described in leukemia [147–149] and are represented here. All mutations produce truncated proteins that are not functional, except for the two SNV identified in B-cell precursors ALL. NLS: nuclear localization signal, ALL: acute lymphoblastic leukemia