Table 1.
Summary of the current literature on DNA and RNA-FUBP1 binding regions and related functions
| Gene | Localization, role of FUBP1 and DNA or RNA sequence | References | Motif | |
|---|---|---|---|---|
| DNA bindings | MYC |
− 1.7 kb upstream the P2 promoter (strand −) Transcriptional activation |
[3, 34, 41, 43, 55] | A/T-rich |
| GTATATTCCCTCGGGATTTTTTATTTTGTGTTATTCCACGGCATGAAAAA | ||||
| USP29 |
− 2.5 kb upstream TSS (strand −) Transcriptional activation |
[5] | T- and GT- rich | |
| TTTGCATTACTTTTTTTTTTGTTTGTTTTTGAGATGGAGTTTTGCTCTTGTTGCCC | ||||
| c-KIT |
+ 30 kb upstream TSS (strand +) Transcriptional activation |
[44] | A/T-rich | |
| AGTTTATTCCTATGGGGATATAAAAGTGTGTCAG | ||||
| CDKN1A |
− 2.7 kb upstream TSS (strand −) Transcriptional repression |
[8, 11, 32] | T- and GT- rich | |
| CTGGCTTTTTGTTTTCATTTTGTTTTTTTGTTTTGTTTTGTTTTTTGAGACAA | ||||
| BIK |
− 1.2 kb upstream TSS (strand −) Transcriptional repression |
[11] | T- and GT- rich | |
| CTTTTGTGGGGTTTTTTTGTTTGTTTTTGTTTTTGTTTTTTTGA | ||||
| RNA bindings | PKD2 |
3′UTR Translational repression |
[80] |
AU- and AUUUA-rich |
| 691nt…CCUAAAGAUUUAUCUGCAUAUUCUUUUUCCCAUGUGGCUCUACUCAUUUGCAACUGAAUUUAAUGUU…1044nt | ||||
| GAP-43 |
3′UTR mRNA degradation |
[81] | CU-rich | |
| GUCCACUUUCCUCUCUCUCUCUCUCU | ||||
| COX2 |
3′UTR Unknown |
[73] |
AU- and AUUUA-rich |
|
| AAGUCUAAUGAUCAUAUUUAUUUAUUUAUAUGAACCAUGUCUAUUAAUUUAAUUAUUUAAUAAUAUUUAUAUUAAA | ||||
| P27 |
5′UTR: 32–40 nucleotides upstream the start codon Translational activation |
[85] | ||
| GCGAAGAG | ||||
| Triadin |
Exon 10 on an exonic splicing silencer Suppression of the exon 10 splicing |
[94] | AU-rich | |
| GUCGAUAUAUGAUUGA | ||||
| MDM2 |
Intron 11 on an intronic splicing enhancer Activation of the exon 11 splicing inclusion |
[78] | U- and GU-rich | |
| AAUUCCCUUUCUUGUGUGUAUGGU | ||||
| DMD |
Intron 38 on an intronic splicing enhancer Activation of the exon exon 39 splicing inclusion |
[79] | U- and GU-rich | |
| GGAUUUUUGUGUGUGUUUAAAUAACAUGUCUUAUUA | ||||
| Hepatitis C virus |
3′UTR Enhances replication. |
[74] | U- and UC-rich | |
| Poly(U/UC) region | ||||
| EV71 |
5′UTR, in the IRES Enhances viral protein synthesis. |
[86, 88] | U- and AU- rich | |
| 636nt…CAAUUGUUUACCUAUUUAUUGGUUUUGUACCAUUAUCACUGAAGUCUGUGAUCACUCUCAAAUUCAUUUUGACCC…745nt | ||||
The specific nucleotides (nt) required for FUBP1 binding are underlined