Fig. 3.

Schematic representation of animal cytokinesis. Progress of furrow ingression results in a thin plasma bridge termed intercellular bridge (ICB). At the middle of ICB, there is an electron dense structure called midbody (Flemming body). The centralspindlin components recruit among others phospho-syndecan-4 (green) and CEP55 to the midbody. CEP55 interacts with the adaptor protein ALIX and the ESCRT-I protein TSG101, which are in turn proposed to recruit ESCRT-III components (CHMP2,-3,-4,-5,-6) with the microtubule-severing enzyme spastin [47]. The cortical constriction of the membrane is driven by VPS4, which leads to abscission