Fig. 8.

Graphical summary of results and postulated mechanism. The CFTR failure induces intracellular Cl⁻ accumulation [47, 49], produces IL-1β secretion [21, 48], inhibition of mCx-I [16, 19, 20], increased c-Src activity and ROS levels [21, 26, 68]. This leads to the activation of LDH, production/secretion of lactate, and reduction of the pHe, partially through c-Src and JNK signaling pathways. In Caco-2/pRS26 cells the LDH and the lactate contribute entirely to the reduction of pHe, since oxamate completely reverted the low pHe of these CFTR-KD cells to the value of control cells. Doted lines (…) represent previously obtained results