Fig. 6.

Studies to generate naïve human pluripotent stem cells [135–155]. Naïve pluripotency can be established in human cells by direct reprograming of human somatic cells, conversion of conventional primed hESCs/hiPSCs into the naïve pluripotent state, and by direct naïve ESC derivation from pre-implantation embryos via overexpression of pluripotency-related transcription factors or modification of the culture conditions. Current naïve human PSCs require additional efforts in respect of differentiation potential and genome integrity. hiPSCs human induced pluripotent stem cells, hESCs human embryonic stem cells, hPSCs human pluripotent stem cells, hLIF human LIF, PD PD0325901, Mek inhibitor, CHIR CHIR99021, GSK3β inhibitor, A83 A-83-01, ALK4/5/7 inhibitor, FK forskolin, protein kinase A agonist, SB20 SB203580, p38 inhibitor, SAHA suberoylanilide hydroxamic acid or vorinostat, pan-histone deacetylase (HDAC) inhibitor, LPA lysophosphatidic acid, YAP agonist, LRH1 liver receptor homologue 1 or Nr5a2, RARG retinoic acid receptor gamma, XAV939 tankyrase inhibitor