Table 1.
Summary of the PMCA2-interacting proteins identified by IP-MS
| Gene symbol | Protein name | ||
|---|---|---|---|
| I. Known PMCA2-interacting partners (with experimental evidence) | |||
| *Ref. [19] | PDLIM7 | PDZ and LIM domain protein 7 | |
| Ref. [32] | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (calcineurin) | |
| Ref. [32] | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (calcineurin) | |
| Ref. [32] | PPP6C | Serine/threonine-protein phosphatase 6 catalytic subunit (calcineurin) | |
| Ref. [32] | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (calcineurin) | |
| Ref. [32] | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (calcineurin) | |
| Ref. [32] | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (calcineurin) | |
| Refs. [33, 34] | PRKCD | Protein kinase C delta type | |
| IIa. Potential PMCA2-interacting partners based on STRING analysis (high confidence: score ≥ 0.70) | |||
| – | – (None detected) | ||
| IIb. Potential PMCA2-interacting partners based on STRING analysis (medium confidence: 0.40 < score < 0.70) | |||
| ATP12A | Potassium-transporting ATPase alpha chain 2 | ||
| ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2 | ||
| ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 | ||
| ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha-4 | ||
| IIc. Potential PMCA2-interacting partners based on STRING analysis (low confidence: 0.15 < score ≤ 0.40) | |||
| DAPK1 | Death-associated protein kinase 1 (calcium/calmodulin-dependent serine/threonine kinase) | ||
| DAPK3 | Death-associated protein kinase 3 (calcium/calmodulin-dependent serine/threonine kinase) | ||
| EPHA2 | Ephrin type-A receptor 2 | ||
| #,* | GDI2 | Rab GDP dissociation inhibitor 2 | |
| MCU | Calcium uniporter protein, mitochondrial | ||
| MOCS3 | Adenylyltransferase and sulfurtransferase MOCS3 | ||
| MYL1 | Myosin light chain 1/3, skeletal muscle isoform | ||
| NKRF | NF-kappa-B-repressing factor | ||
| NSF | Vesicle-fusing ATPase | ||
| POTEF | POTE ankyrin domain family member F | ||
| POTFJ | POTE ankyrin domain family member J | ||
| RPS27A | Ubiquitin-40S ribosomal protein S27a | ||
| TRIP13 | Pachytene checkpoint protein 2 homolog | ||
| UBB | Polyubiquitin-B | ||
| UMPS | Uridine 5′-monophosphate synthase | ||
| XPO1 | Exportin-1 | ||
| III. Novel PMCA2-interacting partners | |||
| YWHAQ | 14-3-3 protein theta | ||
| PSMC4 | 26S protease regulatory subunit 6B | ||
| PSMC2 | 26S protease regulatory subunit 7 | ||
| PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | ||
| PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | ||
| PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | ||
| PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | ||
| OGDH | 2-Oxoglutarate dehydrogenase, mitochondrial | ||
| OGDHL | 2-Oxoglutarate dehydrogenase-like, mitochondrial | ||
| BCKDHB | 2-Oxoisovalerate dehydrogenase subunit beta, mitochondrial | ||
| RPSA | 40S ribosomal protein SA | ||
| PRKAA1 | 5′-AMP-activated protein kinase catalytic subunit alpha-1 | ||
| HSPD1 | 60 kDa heat shock protein, mitochondrial | ||
| RPLP0 | 60S acidic ribosomal protein P0 | ||
| RPL10 | 60S ribosomal protein L10 | ||
| RPL3 | 60S ribosomal protein L3 | ||
| RPL5 | 60S ribosomal protein L5 | ||
| RPL6 | 60S ribosomal protein L6 | ||
| ABI1 | Abl interactor 1 | ||
| ABLIM3 | Actin-binding LIM protein 3 | ||
| TRIP4 | Activating signal cointegrator 1 | ||
| ACAD11 | Acyl-CoA dehydrogenase family member 11 | ||
| SLC25A4 | ADP/ATP translocase 1 | ||
| SLC25A31 | ADP/ATP translocase 4 | ||
| AKAP8 | A-kinase anchor protein 8 | ||
| ALDH7A1 | Alpha-aminoadipic semialdehyde dehydrogenase | ||
| CSN1S2A | Alpha-S2-casein-like A | ||
| ALYREF2 | Aly/REF export factor 2 | ||
| ACE2 | Angiotensin-converting enzyme 2 | ||
| ANKEF1 | Ankyrin repeat and EF-hand domain-containing protein 1 | ||
| ASB7 | Ankyrin repeat and SOCS box protein 7 | ||
| # | ANXA1 | Annexin A1 | |
| AP1B1 | AP-1 complex subunit beta-1 | ||
| AP1M1 | AP-1 complex subunit mu-1 | ||
| AP1M2 | AP-1 complex subunit mu-2 | ||
| AP2B1 | AP-2 complex subunit beta | ||
| AP2M1 | AP-2 complex subunit mu | ||
| A1CF | APOBEC1 complementation factor | ||
| GOT2 | Aspartate aminotransferase, mitochondrial | ||
| DARS | Aspartate–tRNA ligase, cytoplasmic | ||
| ATAD3A | ATPase family AAA domain-containing protein 3A | ||
| ATAD3B | ATPase family AAA domain-containing protein 3B | ||
| ABCE1 | ATP-binding cassette sub-family E member 1 | ||
| ABCF3 | ATP-binding cassette sub-family F member 3 | ||
| ACLY | ATP-citrate synthase | ||
| PFKP | ATP-dependent 6-phosphofructokinase, platelet type | ||
| DDX1 | ATP-dependent RNA helicase DDX1 | ||
| DDX39A | ATP-dependent RNA helicase DDX39A | ||
| DHX8 | ATP-dependent RNA helicase DHX8 | ||
| YME1L1 | ATP-dependent zinc metalloprotease YME1L1 | ||
| EPB41L5 | Band 4.1-like protein 5 | ||
| BZW2 | Basic leucine zipper and W2 domain-containing protein 2 | ||
| ENO3 | Beta-enolase | ||
| EPRS | Bifunctional glutamate/proline–tRNA ligase | ||
| MTHFD2 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | ||
| BRCA2 | Breast cancer type 2 susceptibility protein homolog | ||
| BTBD9 | BTB/POZ domain-containing protein 9 | ||
| BYSL | Bystin | ||
| CAD | CAD protein | ||
| CALU | Calumenin | ||
| CTSZ | Cathepsin Z | ||
| CCAR2 | Cell cycle and apoptosis regulator protein 2 | ||
| CDC45 | Cell division control protein 45 homolog | ||
| CDC5L | Cell division cycle 5-like protein | ||
| CDC123 | Cell division cycle protein 123 homolog | ||
| CENPV | Centromere protein V | ||
| CEP104 | Centrosomal protein of 104 kDa | ||
| CEP164 | Centrosomal protein of 164 kDa | ||
| CLIC1 | Chloride intracellular channel protein 1 | ||
| CHAF1B | Chromatin assembly factor 1 subunit B | ||
| † | SNAP91 | Clathrin coat assembly protein AP180 | |
| CPSF3 | Cleavage and polyadenylation specificity factor subunit 3 | ||
| CLPTM1 | Cleft lip and palate transmembrane protein 1 homolog | ||
| ARCN1 | Coatomer subunit delta | ||
| CCDC28A | Coiled-coil domain-containing protein 28A | ||
| CCDC61 | Coiled-coil domain-containing protein 61 | ||
| CHCHD3 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial | ||
| COL4A2 | Collagen alpha-2(IV) chain | ||
| FAM120A | Constitutive coactivator of PPAR-gamma-like protein 1 | ||
| FAM120C | Constitutive coactivator of PPAR-gamma-like protein 2 | ||
| H2AFY | Core histone macro-H2A.1 | ||
| H2AFY2 | Core histone macro-H2A.2 | ||
| CORO6 | Coronin-6 | ||
| CUL1 | Cullin-1 | ||
| CDK17 | Cyclin-dependent kinase 17 | ||
| CDK20 | Cyclin-dependent kinase 20 | ||
| CLNK | Cytokine-dependent hematopoietic cell linker | ||
| CKAP2 | Cytoskeleton-associated protein 2 | ||
| AGBL1 | Cytosolic carboxypeptidase 4 | ||
| ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase | ||
| DNASE1L1 | Deoxyribonuclease-1-like 1 | ||
| DGKB | Diacylglycerol kinase beta | ||
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | ||
| DPYS | Dihydropyrimidinase | ||
| CRMP1 | Dihydropyrimidinase-related protein 1 | ||
| DPYSL2 | Dihydropyrimidinase-related protein 2 | ||
| MLH1 | DNA mismatch repair protein Mlh1 | ||
| MSH2 | DNA mismatch repair protein Msh2 | ||
| POLB | DNA polymerase beta | ||
| MCM5 | DNA replication licensing factor MCM5 | ||
| TOP2B | DNA topoisomerase 2-beta | ||
| TOP1MT | DNA topoisomerase I, mitochondrial | ||
| DNAJA1 | DnaJ homolog subfamily A member 1 | ||
| DNAJA2 | DnaJ homolog subfamily A member 2 | ||
| DNAJB12 | DnaJ homolog subfamily B member 12 | ||
| DNAJC10 | DnaJ homolog subfamily C member 10 | ||
| DNAJC11 | DnaJ homolog subfamily C member 11 | ||
| DDOST | Dolichyl-diphosphooligosaccharide–protein glycosyltransferase 48 kDa subunit | ||
| RPN1 | Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 1 | ||
| RPN2 | Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 2 | ||
| STAU1 | Double-stranded RNA-binding protein Staufen homolog 1 | ||
| DBNL | Drebrin-like protein | ||
| DSTYK | Dual serine/threonine and tyrosine protein kinase | ||
| DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | ||
| † | DNM3 | Dynamin-3 | |
| DST | Dystonin | ||
| DTNA | Dystrobrevin alpha | ||
| DTNB | Dystrobrevin beta | ||
| RANBP2 | E3 SUMO-protein ligase RanBP2 | ||
| TRIM39 | E3 ubiquitin-protein ligase TRIM39 | ||
| TRIM56 | E3 ubiquitin-protein ligase TRIM56 | ||
| UHRF1 | E3 ubiquitin-protein ligase UHRF1 | ||
| EML4 | Echinoderm microtubule-associated protein-like 4 | ||
| † | EHD1 | EH domain-containing protein 1 | |
| † | EHD2 | EH domain-containing protein 2 | |
| † | EHD3 | EH domain-containing protein 3 | |
| † | EHD4 | EH domain-containing protein 4 | |
| ELAVL4 | ELAV-like protein 4 | ||
| ETFA | Electron transfer flavoprotein subunit alpha, mitochondrial | ||
| EEF1A2 | Elongation factor 1-alpha 2 | ||
| EEF1D | Elongation factor 1-delta | ||
| EEF1G | Elongation factor 1-gamma | ||
| ENDOD1 | Endonuclease domain-containing 1 protein | ||
| EPS8 | Epidermal growth factor receptor kinase substrate 8 | ||
| EPS8L2 | Epidermal growth factor receptor kinase substrate 8-like protein 2 | ||
| ERLIN1 | Erlin-1 | ||
| ERLIN2 | Erlin-2 | ||
| EIF4A3 | Eukaryotic initiation factor 4A-III | ||
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B | ||
| EIF2S3 | Eukaryotic translation initiation factor 2 subunit 3 | ||
| EIF2S3Y | Eukaryotic translation initiation factor 2 subunit 3, Y-linked | ||
| EIF3B | Eukaryotic translation initiation factor 3 subunit B | ||
| EIF3C | Eukaryotic translation initiation factor 3 subunit C | ||
| EIF3D | Eukaryotic translation initiation factor 3 subunit D | ||
| EIF3E | Eukaryotic translation initiation factor 3 subunit E | ||
| DIS3 | Exosome complex exonuclease RRP44 | ||
| XPO4 | Exportin-4 | ||
| XPO7 | Exportin-7 | ||
| XPOT | Exportin-T | ||
| CAPZA2 | F-actin-capping protein subunit alpha-2 | ||
| KHSRP | Far upstream element-binding protein 2 | ||
| FAF2 | FAS-associated factor 2 | ||
| FAR1 | Fatty acyl-CoA reductase 1 | ||
| FOLR2 | Folate receptor beta | ||
| FHL2 | Four and a half LIM domains protein 2 | ||
| FMR1 | Fragile X mental retardation protein 1 | ||
| FXR2 | Fragile X mental retardation syndrome-related protein 2 | ||
| ALDOA | Fructose-bisphosphate aldolase A | ||
| LGALS8 | Galectin-8 | ||
| GMDS | GDP-mannose 4,6 dehydratase | ||
| GMIP | GEM-interacting protein | ||
| GLUD1 | Glutamate dehydrogenase 1, mitochondrial | ||
| GLUD2 | Glutamate dehydrogenase 2, mitochondrial | ||
| GFPT1 | Glutamine–fructose-6-phosphate aminotransferase [isomerizing] 1 | ||
| GFPT2 | Glutamine–fructose-6-phosphate aminotransferase [isomerizing] 2 | ||
| QARS | Glutamine–tRNA ligase | ||
| AGL | Glycogen debranching enzyme | ||
| GTDC1 | Glycosyltransferase-like domain-containing protein 1 | ||
| GOLGB1 | Golgin subfamily B member 1 | ||
| GBF1 | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 | ||
| GRN | Granulins | ||
| RAN | GTP-binding nuclear protein Ran | ||
| GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | ||
| GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | ||
| GNAO1 | Guanine nucleotide-binding protein G(o) subunit alpha | ||
| GNAL | Guanine nucleotide-binding protein G(olf) subunit alpha | ||
| GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | ||
| GNAT1 | Guanine nucleotide-binding protein G(t) subunit alpha-1 | ||
| GNA11 | Guanine nucleotide-binding protein subunit alpha-11 | ||
| GNA14 | Guanine nucleotide-binding protein subunit alpha-14 | ||
| GNA15 | Guanine nucleotide-binding protein subunit alpha-15 | ||
| CLCN3 | H(+)/Cl(−) exchange transporter 3 | ||
| CLCN5 | H(+)/Cl(−) exchange transporter 5 | ||
| DKC1 | H/ACA ribonucleoprotein complex subunit 4 | ||
| HHIP | Hedgehog-interacting protein | ||
| HNF1B | Hepatocyte nuclear factor 1-beta | ||
| # | HNRNPA1L2 | Heterogeneous nuclear ribonucleoprotein A1-like 2 | |
| HNRNPD | Heterogeneous nuclear ribonucleoprotein D0 | ||
| HNRNPH2 | Heterogeneous nuclear ribonucleoprotein H2 | ||
| HNRNPK | Heterogeneous nuclear ribonucleoprotein K | ||
| HNRNPL | Heterogeneous nuclear ribonucleoprotein L | ||
| HK1 | Hexokinase-1 | ||
| HK2 | Hexokinase-2 | ||
| HK3 | Hexokinase-3 | ||
| KAT2B | Histone acetyltransferase KAT2B | ||
| HDAC1 | Histone deacetylase 1 | ||
| HDAC2 | Histone deacetylase 2 | ||
| HIST1H1A | Histone H1.1 | ||
| HIST1H1C | Histone H1.2 | ||
| HIST1H1D | Histone H1.3 | ||
| HIST1H1T | Histone H1t | ||
| H2AFX | Histone H2AX | ||
| H2BFS | Histone H2B type F-S | ||
| H3F3C | Histone H3.3C | ||
| RBBP4 | Histone-binding protein RBBP4 | ||
| RBBP7 | Histone-binding protein RBBP7 | ||
| KMT2A | Histone-lysine N-methyltransferase 2A | ||
| HMBOX1 | Homeobox-containing protein 1 | ||
| KPNB1 | Importin subunit beta-1 | ||
| IGF2BP1 | Insulin-like growth factor 2 mRNA-binding protein 1 | ||
| IGF2BP2 | Insulin-like growth factor 2 mRNA-binding protein 2 | ||
| IGF2BP3 | Insulin-like growth factor 2 mRNA-binding protein 3 | ||
| ITGA2 | Integrin alpha-2 (fragment) | ||
| ITGB4 | Integrin beta-4 | ||
| IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 | ||
| IDH3B | Isocitrate dehydrogenase (NAD) subunit beta, mitochondrial | ||
| KLHDC7A | Kelch domain-containing protein 7A | ||
| KEAP1 | Kelch-like ECH-associated protein 1 | ||
| KLHL7 | Kelch-like protein 7 | ||
| KLHL9 | Kelch-like protein 9 | ||
| KHDRBS1 | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | ||
| KIF12 | Kinesin-like protein KIF12 | ||
| KIF13B | Kinesin-like protein KIF13B | ||
| KIF1A | Kinesin-like protein KIF1A | ||
| KIF1B | Kinesin-like protein KIF1B | ||
| KIF1C | Kinesin-like protein KIF1C | ||
| KIF20A | Kinesin-like protein KIF20A | ||
| KIF2B | Kinesin-like protein KIF2B | ||
| KIF2C | Kinesin-like protein KIF2C | ||
| KIFC1 | Kinesin-like protein KIFC1 | ||
| LMNB2 | Lamin-B2 | ||
| LCA5L | Lebercilin-like protein | ||
| LZTS1 | Leucine zipper putative tumor suppressor 1 | ||
| LZTS3 | Leucine zipper putative tumor suppressor 3 | ||
| LRCH1 | Leucine-rich repeat and calponin homology domain-containing protein 1 | ||
| LRCH2 | Leucine-rich repeat and calponin homology domain-containing protein 2 | ||
| LRGUK | Leucine-rich repeat and guanylate kinase domain-containing protein | ||
| LRRC59 | Leucine-rich repeat-containing protein 59 | ||
| LPPR1 | Lipid phosphate phosphatase-related protein type 1 | ||
| ACSL3 | Long-chain-fatty-acid–CoA ligase 3 | ||
| ACSL4 | Long-chain-fatty-acid–CoA ligase 4 | ||
| HELLS | Lymphoid-specific helicase | ||
| KDM7A | Lysine-specific demethylase 7A | ||
| LYG2 | Lysozyme g-like protein 2 | ||
| MVP | Major vault protein | ||
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | ||
| MELK | Maternal embryonic leucine zipper kinase | ||
| PAQR8 | Membrane progestin receptor beta | ||
| # | MTA1 | Metastasis-associated protein MTA1 | |
| MTA2 | Metastasis-associated protein MTA2 | ||
| MTA3 | Metastasis-associated protein MTA3 | ||
| MARS | Methionine–tRNA ligase, cytoplasmic | ||
| MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | ||
| MINK1 | Misshapen-like kinase 1 | ||
| #,* | SLC25A22 | Mitochondrial glutamate carrier 1 | |
| #,* | SLC25A18 | Mitochondrial glutamate carrier 2 | |
| † | RHOT1 | Mitochondrial Rho GTPase 1 | |
| MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | ||
| BUB3 | Mitotic checkpoint protein BUB3 | ||
| MISP | Mitotic interactor and substrate of PLK1 | ||
| NIFK | MKI67 FHA domain-interacting nucleolar phosphoprotein | ||
| SMAD2 | Mothers against decapentaplegic homolog 2 | ||
| SMAD3 | Mothers against decapentaplegic homolog 3 | ||
| SMAD9 | Mothers against decapentaplegic homolog 9 | ||
| MYD88 | Myeloid differentiation primary response protein MyD88 | ||
| NAT10 | N-acetyltransferase 10 | ||
| NCKIPSD | NCK-interacting protein with SH3 domain | ||
| NBEAL2 | Neurobeachin-like protein 2 | ||
| NEFL | Neurofilament light polypeptide | ||
| NAV3 | Neuron navigator 3 | ||
| NPY5R | Neuropeptide Y receptor type 5 | ||
| FAM129B | Niban-like protein 1 | ||
| NCBP1 | Nuclear cap-binding protein subunit 1 | ||
| NUFIP2 | Nuclear fragile X mental retardation-interacting protein 2 | ||
| NUP93 | Nuclear pore complex protein Nup93 | ||
| NCOA5 | Nuclear receptor coactivator 5 | ||
| YBX1 | Nuclease-sensitive element-binding protein 1 | ||
| NOL6 | Nucleolar protein 6 | ||
| UBTF | Nucleolar transcription factor 1 | ||
| TIAL1 | Nucleolysin TIAR | ||
| NPM1 | Nucleophosmin | ||
| OR6N2 | Olfactory receptor 6N2 | ||
| OAT | Ornithine aminotransferase, mitochondrial | ||
| CDC73 | Parafibromin | ||
| PCID2 | PCI domain-containing protein 2 | ||
| GIPC1 | PDZ domain-containing protein GIPC1 | ||
| PCM1 | Pericentriolar material 1 protein | ||
| † | PICALM | Phosphatidylinositol-binding clathrin assembly protein | |
| PGM3 | Phosphoacetylglucosamine mutase | ||
| # | ATP2B2 | Plasma membrane calcium-transporting ATPase 2 | |
| PAPOLA | Poly(A) polymerase alpha | ||
| PAPOLB | Poly(A) polymerase beta | ||
| PCBP3 | Poly(rC)-binding protein 3 | ||
| PABPC1L | Polyadenylate-binding protein 1-like | ||
| PABPC4L | Polyadenylate-binding protein 4-like | ||
| POLDIP3 | Polymerase delta-interacting protein 3 | ||
| PTBP2 | Polypyrimidine tract-binding protein 2 | ||
| PTBP3 | Polypyrimidine tract-binding protein 3 | ||
| PRPF19 | Pre-mRNA-processing factor 19 | ||
| DDX20 | Probable ATP-dependent RNA helicase DDX20 | ||
| DDX4 | Probable ATP-dependent RNA helicase DDX4 | ||
| DDX47 | Probable ATP-dependent RNA helicase DDX47 | ||
| SETX | Probable helicase senataxin | ||
| RBM46 | Probable RNA-binding protein 46 | ||
| † | PDCD6IP | Programmed cell death 6-interacting protein (Alix) | |
| PCNA | Proliferating cell nuclear antigen | ||
| AGO2 | Protein argonaute-2 | ||
| CYR61 | Protein CYR61 | ||
| FAM83B | Protein FAM83B | ||
| PRRC2A | Protein PRRC2A | ||
| RCC2 | Protein RCC2 | ||
| TBRG4 | Protein TBRG4 | ||
| TFG | Protein TFG | ||
| SEC23B | Protein transport protein Sec23B | ||
| ZYG11B | Protein zyg-11 homolog B | ||
| LOX | Protein-lysine 6-oxidase | ||
| NPEPPSL1 | Puromycin-sensitive aminopeptidase-like protein | ||
| HSP90B2P | Putative endoplasmin-like protein | ||
| EIF2S3L | Putative eukaryotic translation initiation factor 2 subunit 3-like protein | ||
| # | HSPA7 | Putative heat shock 70 kDa protein 7 | |
| # | HSP90AA2 | Putative heat shock protein HSP 90-alpha A2 | |
| # | HSP90AA5P | Putative heat shock protein HSP 90-alpha A | |
| # | HSP90AB4P | Putative heat shock protein HSP 90-beta 4 | |
| DHX16 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 | ||
| PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | ||
| RAB11FIP1 | Rab11 family-interacting protein 1 | ||
| RACGAP1 | Rac GTPase-activating protein 1 | ||
| RAF1 | RAF proto-oncogene serine/threonine-protein kinase | ||
| RALBP1 | RalA-binding protein 1 | ||
| RANGAP1 | Ran GTPase-activating protein 1 | ||
| G3BP1 | Ras GTPase-activating protein-binding protein 1 | ||
| G3BP2 | Ras GTPase-activating protein-binding protein 2 | ||
| IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | ||
| † | RAC1 | Ras-related C3 botulinum toxin substrate 1 | |
| † | RAC3 | Ras-related C3 botulinum toxin substrate 3 | |
| † | RAB1A | Ras-related protein Rab-1A | |
| RAB26 | Ras-related protein Rab-26 | ||
| RAB37 | Ras-related protein Rab-37 | ||
| RAB39B | Ras-related protein Rab-39B | ||
| #,*,† | RAB5A | Ras-related protein Rab-5A | |
| RCC1 | Regulator of chromosome condensation | ||
| RFC2 | Replication factor C subunit 2 | ||
| RFC4 | Replication factor C subunit 4 | ||
| RFC5 | Replication factor C subunit 5 | ||
| RPA1 | Replication protein A 70 kDa DNA-binding subunit | ||
| RTKN | Rhotekin | ||
| RRM1 | Ribonucleoside-diphosphate reductase large subunit | ||
| BOP1 | Ribosome biogenesis protein BOP1 | ||
| RCL1 | RNA 3′-terminal phosphate cyclase-like protein | ||
| RBM47 | RNA-binding protein 47 | ||
| RALY | RNA-binding protein Raly | ||
| CROCC | Rootletin | ||
| RUVBL1 | RuvB-like 1 | ||
| RUVBL2 | RuvB-like 2 | ||
| MAT1A | S-adenosylmethionine synthase isoform type-1 | ||
| MAT2A | S-adenosylmethionine synthase isoform type-2 | ||
| SEPT10 | Septin-10 | ||
| SEPT11 | Septin-11 | ||
| SEPT14 | Septin-14 | ||
| SEPT6 | Septin-6 | ||
| SEPT7 | Septin-7 | ||
| SEPT8 | Septin-8 | ||
| SEPT9 | Septin-9 | ||
| SQSTM1 | Sequestosome-1 | ||
| SHMT2 | Serine hydroxymethyltransferase, mitochondrial | ||
| SRSF2 | Serine/arginine-rich splicing factor 2 | ||
| SRSF8 | Serine/arginine-rich splicing factor 8 | ||
| ARAF | Serine/threonine-protein kinase A-Raf | ||
| BRAF | Serine/threonine-protein kinase B-raf | ||
| MARK1 | Serine/threonine-protein kinase MARK1 | ||
| MARK2 | Serine/threonine-protein kinase MARK2 | ||
| CDC42BPB | Serine/threonine-protein kinase MRCK beta | ||
| NEK5 | Serine/threonine-protein kinase Nek5 | ||
| PAK2 | Serine/threonine-protein kinase PAK 2 | ||
| PLK1 | Serine/threonine-protein kinase PLK1 | ||
| SH3BP4 | SH3 domain-binding protein 4 | ||
| SNRPN | Small nuclear ribonucleoprotein-associated protein N | ||
| SMTN | Smoothelin | ||
| SNW1 | SNW domain-containing protein 1 | ||
| SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1 | ||
| SLC22A4 | Solute carrier family 22 member 4 | ||
| † | SNX2 | Sorting nexin-2 | |
| STRBP | Spermatid perinuclear RNA-binding protein | ||
| DDX39B | Spliceosome RNA helicase DDX39B | ||
| SF3B2 | Splicing factor 3B subunit 2 | ||
| SFPQ | Splicing factor, proline- and glutamine-rich | ||
| CTTN | Src substrate cortactin | ||
| SRPK1 | SRSF protein kinase 1 | ||
| STOML3 | Stomatin-like protein 3 | ||
| SMC2 | Structural maintenance of chromosomes protein 2 | ||
| SDHA | Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial | ||
| SUN2 | SUN domain-containing protein 2 | ||
| SKIV2L2 | Superkiller viralicidic activity 2-like 2 | ||
| VAT1 | Synaptic vesicle membrane protein VAT-1 homolog | ||
| SYTL3 | Synaptotagmin-like protein 3 | ||
| STXBP2 | Syntaxin-binding protein 2 | ||
| TLN1 | Talin-1 | ||
| TARDBP | TAR DNA-binding protein 43 | ||
| TPX2 | Targeting protein for Xklp2 | ||
| TBPL2 | TATA box-binding protein-like protein 2 | ||
| TAX1BP1 | Tax1-binding protein 1 homolog | ||
| CCT2 | T-complex protein 1 subunit beta | ||
| CCT7 | T-complex protein 1 subunit eta | ||
| CCT6A | T-complex protein 1 subunit zeta | ||
| CCT6B | T-complex protein 1 subunit zeta-2 | ||
| TES | Testin | ||
| † | TOM1L2 | TOM1-like protein 2 | |
| TNIK | TRAF2 and NCK-interacting protein kinase | ||
| TTF2 | Transcription termination factor 2 | ||
| TBL3 | Transducin beta-like protein 3 | ||
| TKTL1 | Transketolase-like protein 1 | ||
| SSR1 | Translocon-associated protein subunit alpha | ||
| TNPO3 | Transportin-3 | ||
| HADHB | Trifunctional enzyme subunit beta, mitochondrial | ||
| RTCB | tRNA-splicing ligase RtcB homolog | ||
| TMOD1 | Tropomodulin-1 | ||
| TMOD2 | Tropomodulin-2 | ||
| TUBAL3 | Tubulin alpha chain-like 3 | ||
| TUBA3A | Tubulin alpha-3 chain | ||
| # | TUBB2A | Tubulin beta-2A chain | |
| # | N/A | Tubulin beta-8 chain-like protein LOC260334 | |
| TUBG1 | Tubulin gamma-1 chain | ||
| TUBG2 | Tubulin gamma-2 chain | ||
| TP53I13 | Tumor protein p53-inducible protein 13 | ||
| HCK | Tyrosine-protein kinase HCK | ||
| JAK1 | Tyrosine-protein kinase JAK1 | ||
| UTP15 | U3 small nucleolar RNA-associated protein 15 homolog | ||
| UTP18 | U3 small nucleolar RNA-associated protein 18 homolog | ||
| PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3 | ||
| USP26 | Ubiquitin carboxyl-terminal hydrolase 26 | ||
| USP7 | Ubiquitin carboxyl-terminal hydrolase 7 | ||
| UBA1 | Ubiquitin-like modifier-activating enzyme 1 | ||
| N/A | Uncharacterized protein C2orf57 homolog | ||
| MYO1H | Unconventional myosin-Ih | ||
| UMOD | Uromodulin | ||
| UTS2 | Urotensin-2 | ||
| VPS26A | Vacuolar protein sorting-associated protein 26A | ||
| VPS35 | Vacuolar protein sorting-associated protein 35 | ||
| VASP | Vasodilator-stimulated phosphoprotein | ||
| VTN | Vitronectin | ||
| VDAC1 | Voltage-dependent anion-selective channel protein 1 | ||
| ATP6V1A | V-type proton ATPase catalytic subunit A | ||
| WDR1 | WD repeat-containing protein 1 | ||
| XRCC5 | X-ray repair cross-complementing protein 5 | ||
| YTHDF2 | YTH domain-containing family protein 2 | ||
N/A not applicable
*Different protein isoforms were reported in previous research articles. However, these isoforms exhibit similar function(s)
#Identified as COM crystal-binding proteins in our previous study [31]
†Identified as proteins involved in endocytosis pathway