Fig. 3.

Crosstalk of H3K36 methylation with H3K27 methylation and DNA methylation. In the intergenic regions, the NSD1-catalyzed H3K36me2 prevents spreading of the PRC2-catalyzed H3K27me3, and loss of NSD1 causes genome-wide loss of H3K36me2 and DNA methylation, as well as concomitant gain of H3K27me3. Intrusion and spreading of the PRC2-catalyzed H3K27me3 into the active gene bodies are assisted by PHF1 or PHF19, which mediates ‘reading’ of H3K36me3. Furthermore, CpG island elements recruit KDM2A to remove H3K36me2