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H19 downregulates growth suppressors. a In gastric cancer, H19 interacts physically with p53 to inhibit its antiproliferative activity [47]. bH19 induces the transcriptional inhibition of PHB1 in liver cancer cells [53]. cH19 is able to sponge miR-152 and so enhance glioma cells proliferation [79]. dH19-derived miR-675 inhibits the expression of well-known growth suppressors such as RB and RUNX1 in colorectal and hepatocellular cancers, and in gastric cancer, respectively [48, 69, 85]
