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. 2019 Jul 23;76(23):4673–4687. doi: 10.1007/s00018-019-03240-z

Fig. 3.

Fig. 3

H19 impedes cancer cell death. a In pancreatic cancer cells, H19 prevents caspase 3 cleavage [62]. bH19 sponges miR-138-5p in cervical cancer to allow the transcription of SIRT1 [70]. cH19 is able to physically interact with PRC2 complex to catalyze the trimethylation of H3K27, that will lead to chromatin condensation and repression of pro-apoptotic factor BIK in breast cancer cells [43]. d miR-675 is able to inhibit the expression of pro-apoptotic factors such as Cbl and FADD in breast and gastric cancers, respectively [49, 82]