Table 2.

Mediators of lncRNA H19 action in cancer

Type of cancer	Mediators of H19 action	Impact on hallmarks of cancer	References
Glioma	• miR-152 • miR-29a	• Evading growth suppressors • Inducing angiogenesis	[79] [30]
Tongue squamous cell carcinoma	• EZH2	• Activating invasion and metastasis	[33]
Lung adenocarcinoma	• SAHH	• Genomic instability and mutation	[37]
Breast cancer	• E2F1 • ERα • miR-152	• Sustaining proliferative signaling	[40] [41] [29]
Gastric cancer	• p53 • miR-141 • PEG10	• Evading growth suppressors • Sustaining proliferative signaling • Activating invasion and metastasis	[47] [80] [51]
Liver cancer	• Telomerase complex	• Enabling replicative immortality	[54]
Cholangiocarcinoma	• let-7	• Tumor-promoting inflammation	[61]
Pancreatic cancer	• E2F1	• Sustaining proliferative signaling • Resisting cell death	[62]
Renal cell carcinoma	• miR-29b-3p	• Activating invasion and metastasis	[63]
Bladder cancer	• miR-29b-3p • EZH2	• Sustaining proliferative signaling • Resisting cell death • Activating invasion and metastasis	[64] [43] [66]
Colorectal cancer	• eIF4A3 • miR-200a	• Sustaining proliferative signaling	[67] [68]
Cervical cancer	• miR-138-5p	• Resisting cell death	[70]
Leukemia	• Telomerase complex	• Enabling replicative immortality	[74]
Osteosarcoma	• miR-200	• Activating invasion and metastasis	[75]
Melanoma	• miR-106a-5p	• Deregulating cell energetics	[76]