Table 3.
Validated targets of H19-derived miR-675 in cancer
| Type of cancer | Targets of miR-675 | Target function | References |
|---|---|---|---|
| Glioma | • Cadherin 13 | • Atypical cadherin lacking the cytoplasmic domain | [81] |
| Breast cancer | • Cbl-b, c-Cbl | • Ubiquitin ligases E3 | [45, 82] |
| Lung cancer | • GPR55 | • G protein-coupled receptor | [83] |
| Esophageal squamous cell carcinoma | • REPS2 | • Repressor of cell proliferation and migration | [84] |
| Gastric cancer |
• FADD • RUNX1 • CALN1 |
• Apoptotic adaptator that recruits caspase 8 or 10 • Transcription factor • Calcium-binding protein |
[49] [48] [50] |
| Liver cancer |
• HP1 • RB • TWIST1 |
• Heterochromatin assembler and regulator • Tumor suppressor • Transcription factor involved in EMT |
[56] [85] [85] |
| Colorectal cancer |
• RB • DDB2 |
• Tumor suppressor • Transcriptional repressor |
[69] [86] |
| Ovarian cancer | • Slug | • Transcriptional factor involved in EMT | [39] |
| Osteosarcoma | • CALN1 | • Calcium-binding protein | [87] |