Table 2.

CFTR-related signaling involved in cancer regulation

Cancer type	Signaling factors	Cancer cell behavior	Citations
Reproduction system
Endometrial carcinoma	NF-kB/uPAR and mir-125b	Cell viability and invasiveness	Huang et al. [51] and Xia et al. [50]
Ovarian cancer	Phosphor-Src	Invasiveness and motility	Zhu et al. [46] and Xu et al. [47]
Cervical cancer	Regulated by NF-kB	Unknown	Wu et al. [143]
Breast cancer	NF-kB/uPAR	Migration, invasion, EMT and metastasis	Zhang et al. [76]
Prostate cancer	miR-193b/uPA	Cell viability, clone formation, migration and invasion	Xie et al. [41]
Respiratory system
Nasopharyngeal carcinoma	Unknown	Migration, invasion and EMT	Tu et al. [37]
Lung cancer	uPA/uPAR	Migration, invasion, EMT and metastasis	Li et al. [43]
Digestive system
Esophageal adenocarcinoma	Unknown	Unknown
Hepatocellular carcinoma	IP(3)/G-proteins/PLC/Ca2+	Apoptosis	Kim et al. [134]
Pancreatic adenocarcinoma	MUC4	Unknown	Singh et al. [142]
Gastric cancer	Unknown	Unknown
Intestinal cancer	Wnt/β-catenin pathway; AF-6/MAPK	Tumor formation; cell viability, adhesion, migration, invasion and metastasis	Than et al. [40] and Sun et al. [39]
Urinary system
Bladder cancer	Unknown	Unknown
Endocrine system
Papillary thyroid cancer	Unknown	Unknown