Table 2.
Haploid embryonic development capability and haESC derivation efficiency
| Cell type | Genetic background | Blastocyst (% of 1-cell embryos) | ES derived (% of blastocysts) | Haploid ES (% of ES cell lines) | References |
|---|---|---|---|---|---|
| PG-haESCs | Mixed strainsa | 181/937 (19.32) | 76/181 (42) | 25/76 (32.9) | [15] |
| PG-haESCs | C57BL/6 | 40/86 (46.5)b | 13/40 (32.5) | 9/13 (69.23) | [21] |
| C57BL/6 × CD1 | 14/30 (46.6)b | 6/14 (42.86) | 2/6 (33.33) | [21] | |
| PG-haESCs | C57BL/6 | 79/590 (13.39) | 38/79 (48.10) | 6/38 (15.79) | [22] |
| AG-haESCs | C57(OG-2) | 194/909 (21.34) | 34/194 (17.53) | 4/34 (11.76) | [14] |
| AG-haESCs | Actin-GFP | 82/490 (16.73) | 5/82 (6.1) | 1/5 (20) | [14] |
| AG-haESCs | 129sv | 46/244 (17.42) | 7/46 (15.22) | 1/7 (14.29) | [36] |
| AG-haESCs | C57(OG-2) | 110/466 (23.60) | 19/110 (17.27) | 5/19 (26.32) | [36] |
| Rat AG-haESCs | DA | 43/986 (4.36)b | 17/43 (40) | 9/17 (53) | [23] |
| Rat AG-haESCs | WDB-Rosa26em1(RT2)Nips | 26/495 (5.25) | 7/26 (26.92) | 1/7 (14.29) | [24] |
| Rat PG-haESCs | WI-Tg (CAG/Venus)Nips | 2/117 (1.71) | 2/2 (100) | 1/2 (50) | [24] |
| Monkey PG-haESCs |
Macaca Fascicularis monkey |
70/181(40) | 10/70 (14) | 2/10 (20) | [25] |
| Human PG-haESCs | ND | ND | 14 | 2/14 (14.28) | [26] |
| Human PG-haESCs | ND | 6/23 (26.08) | 4/6 (66.67) | 2/4 (50) | [27] |
ND not determined
aMixed mouse strains included B6CBAF1, 129B6F1, 129sv, transgenic ROSA26nlsrtTA LC1 Xist2LOX and ROSA26nlsrtTA tetOPXist
bData were obtained from morulae and blastocysts