Table 2.
Fumarate (µM) | Succinate (µM) | R-2-hydroxyglutarate (µM) | S-2-hydroxyglutarate (µM) | Citrate (µM) | |
---|---|---|---|---|---|
TET1 | 390a | 540a | 4000b | 1000b | > 5000a |
TET2 | 400a | 570a | 5000b | 1600b | > 5000a |
HIF-P4H-1 | 120c | 830c | Not an inhibitorb | 630b,d | 6300c |
HIF-P4H-2 | 80c | 510c | Not an inhibitorb/7300e | 1150b,d | 4800c |
HIF-P4H-3 | 60c | 570c | Not an inhibitorb | 90b,d | 550c |
Collagen P4H-I | 190c,d | 400d,f | 1800b | 310b | 450d,g |
FIH | > 10,000c | > 10,000c | 1100–1500b,e | 190–300b,e | 850c |
KDM4A | 1500h | 800h | 20e | 30e | ND |
KDM4C | ND | ND | 80e | 100e | ND |
KDM4E | 2300i | 320i | ND | ND | ND |
ABH2 | ND | ND | 420e | 150e | ND |