. 2017 Nov 28;75(8):1339–1348. doi: 10.1007/s00018-017-2721-8

Table 2.

IC₅₀ values of TETs and several other 2-OGDDs for 2-oxoglutarate analogues

	Fumarate (µM)	Succinate (µM)	R-2-hydroxyglutarate (µM)	S-2-hydroxyglutarate (µM)	Citrate (µM)
TET1	390^a	540^a	4000^b	1000^b	> 5000^a
TET2	400^a	570^a	5000^b	1600^b	> 5000^a
HIF-P4H-1	120^c	830^c	Not an inhibitor^b	630^b,d	6300^c
HIF-P4H-2	80^c	510^c	Not an inhibitor^b/7300^e	1150^b,d	4800^c
HIF-P4H-3	60^c	570^c	Not an inhibitor^b	90^b,d	550^c
Collagen P4H-I	190^c,d	400^d,f	1800^b	310^b	450^d,g
FIH	> 10,000^c	> 10,000^c	1100–1500^b,e	190–300^b,e	850^c
KDM4A	1500^h	800^h	20^e	30^e	ND
KDM4C	ND	ND	80^e	100^e	ND
KDM4E	2300ⁱ	320ⁱ	ND	ND	ND
ABH2	ND	ND	420^e	150^e	ND

ND not determined

^a[15]

^b[60]

^c[83]

^d K _i value

^e[59]

^f[92]

^g[93]

^h[54]

ⁱ[94]