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. 2019 Jul 27;76(23):4613–4633. doi: 10.1007/s00018-019-03233-y

Table 4.

Current clinical trials on exosomes in lung cancer

Title Status Conditions Interventions
Combined diagnosis of CT and exosome in early lung cancer Not yet recruiting Early lung cancer Procedure: surgery
Serum exosomal long noncoding RNAs potential biomarkers for lung cancer diagnosis Recruiting Lung cancer Diagnostic test: collect samples
Clinical research for the consistency analysis of PD-L1 in lung cancer tissue and plasma exosome before and after radiotherapy Unknown NSCLC Radiation: radiotherapy
Dynamic monitoring circulating tumor DNA in surgical patients with lung cancer Recruiting Lung cancer Other: blood samples
Detection of circulating biomarkers of immunogenic cell death Active, not recruiting NSCLC Other: blood samples
Circulating exosome RNA in lung metastases of primary high grade Recruiting Lung metastases
Osteosarcoma Other: blood samples
Olmutinib trial in T790 M (+) NSCLC patients detected by liquid biopsy using BALF extracellular vesicular DNA Active, not recruiting NSCLC Drug: olmutinib
Detection of either the EML4-ALK gene rearrangements or the T790 M EGFR mutation in the plasma of advanced NSCLC patients Active, not recruiting Carcinoma
NSCLC Other: blood samples
Pilot study with the aim to quantify a stress protein in the blood and in the urine for the monitoring and early diagnosis of malignant solid tumor Recruiting Cancer Other: blood samples
Other: urine samples