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. 2017 Sep 14;75(2):291–300. doi: 10.1007/s00018-017-2640-8

Table 1.

Summary of ncRNAs linked to apoptosis in CVDs

ncRNAs Targets/CVDs Pro- or anti-apoptosis References
miR-1 Bcl-2/MI Promotes apoptosis [22]
miR-133a Caspase-9/MI Inhibits apoptosis [24]
miR-17-92 cluster STAT3/MI, HF Induces apoptosis [63, 64]
miR-21 Bcl-2/MI Anti-apoptotic [65]
miR-30 P53/MI Anti-apoptotic [35]
miR-199a Hif1α, Sirt1/MI Anti-apoptotic [29]
miR-320 Hsp20/MI Pro-apoptotic [30]
miR-149 Puma/MI Decreases apoptosis [66]
miR-761 Mff/MI Promotes apoptosis [67]
miR-499 Calcineurin/MI Inhibits apoptosis [68]
miR-214 Pten/MI Anti-apoptotic [69]
miR-145 Bnip3/MI Decreases apoptosis [70]
miR-378 Caspase-3/MI Anti-apoptotic [71]
miR-195 Sirt1/lipotoxic cardiomyopathy Pro-apoptotic [72]
miR-34a Sirt1/coronary artery disease Promotes apoptosis [73]
miR-184 Bcl-xL, Bcl-w/MI Pro-apoptotic [31]
miR-140 Mfn1/MI Induces apoptosis [38]
miR-421 Pink1/MI Promotes apoptosis [4]
miR-324-5p Mtfr 1/MI Anti-apoptotic [42]
miR-361 Phb1/MI Pro-apoptotic [41]
miR-208a GATA4/DOX cardiotoxicity Promotes apoptosis [45]
miR-532-3p ARC/DOX cardiotoxicity Pro-apoptosis [46]
LncRNA-CARL miR-539, Phb2/MI Inhibits apoptosis [56]
CircRNA-HRCR miR-223, arc/cardiac hypertrophy Anti-apoptotic [60]