Table 2.
NcRNAs regulating necrosis and autophagy of cardiomyocytes
ncRNAs | Targets/CVDs | Effects on necrosis/autophagy | References |
---|---|---|---|
miR-155 | Rip1/MI | Decreases necrosis | [83] |
miR-30b | Cyclophilin D/MI | Inhibits necrosis | [82] |
miR-874 | Caspase-8/MI | Promotes necrosis | [84] |
miR-2861 | Ant1/MI | Promotes necrosis | [87] |
lncRNA-H19 | miR-103/107, FADD/MI | Anti-necrosis | [86] |
lncRNA-NRF | miR-873, RIP/MI | Pro-necrosis | [89] |
miR-99a | mTOR/MI | Activates beneficial autophagy | [94] |
miR-22 | PPAR-α/MI | Decreases beneficial autophagy | [101] |
miR-221 | P27/heart failure | Decreases autophagy | [95] |
miR-212/132 | Foxo3a/cardiac hypertrophy | Inhibits beneficial autophagy | [99] |
miR-451 | Tsc1/cardiac hypertrophy | Inhibits harmful autophagy | [100] |
miR-325 | Arc/MI | Promotes autophagy | [96] |
miR-30a | Beclin-1/cardiac hypertrophy | Decreases harmful autophagy | [97] |
miR-34a | Atg9a/cardiac hypertrophy | Inhibits harmful autophagy | [103] |
miR-497 | Lc3b, Bcl2/MI | Anti-autophagic | [104] |
lncRNA-APF | miR-188-3p, Atg7/MI | Promotes autophagy | [102] |