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. 2017 Sep 14;75(2):291–300. doi: 10.1007/s00018-017-2640-8

Table 2.

NcRNAs regulating necrosis and autophagy of cardiomyocytes

ncRNAs Targets/CVDs Effects on necrosis/autophagy References
miR-155 Rip1/MI Decreases necrosis [83]
miR-30b Cyclophilin D/MI Inhibits necrosis [82]
miR-874 Caspase-8/MI Promotes necrosis [84]
miR-2861 Ant1/MI Promotes necrosis [87]
lncRNA-H19 miR-103/107, FADD/MI Anti-necrosis [86]
lncRNA-NRF miR-873, RIP/MI Pro-necrosis [89]
miR-99a mTOR/MI Activates beneficial autophagy [94]
miR-22 PPAR-α/MI Decreases beneficial autophagy [101]
miR-221 P27/heart failure Decreases autophagy [95]
miR-212/132 Foxo3a/cardiac hypertrophy Inhibits beneficial autophagy [99]
miR-451 Tsc1/cardiac hypertrophy Inhibits harmful autophagy [100]
miR-325 Arc/MI Promotes autophagy [96]
miR-30a Beclin-1/cardiac hypertrophy Decreases harmful autophagy [97]
miR-34a Atg9a/cardiac hypertrophy Inhibits harmful autophagy [103]
miR-497 Lc3b, Bcl2/MI Anti-autophagic [104]
lncRNA-APF miR-188-3p, Atg7/MI Promotes autophagy [102]