Fig. 7.

Regulation of β1 integrin activation, subcellular trafficking and degradation by LRP1. a Inactive α5β1 integrin is present in the complex with LRP1 on the cell surface. Upon cell contact with fibronectin, kindlin2 is sequentially recruited to LRP1 (b) and to β1 integrin (c) which results in integrin activation. d Following endocytosis, LRP1 employs myosins to direct ubiquitinated integrins toward lysosomal and proteasomal degradation. The molecular mechanism by which PKC mediates LRP1-induced activation and subsequent trafficking of α5β1 integrin and whether LRP1 remains bound to α5β1 integrin during endocytosis, transport and degradation are currently unknown