Fig. 1.

The mRNA expression pattern of lrp4 in the developing zebrafish. a The ubiquitous expression of lrp4 mRNA during cleavage and gastrula stages. b The dynamic expression of lrp4 mRNA at multiple tissues including the neural tube (NT) and the retina at the head (first row; lateral view with anterior towards the left); pectoral fins and pronephros at the midtrunk (second row; dorsal view with anterior towards the left); the median fin fold, somites, the (posterior) blood island, and actinotrichia forming cells (AFC) in the posterior trunk and tail regions (third row; lateral view with anterior towards the left). Restrictive expression of lrp4 mRNA at rhombic lips and the dorsal spinal chord is evident from the dorsal view, starting from about 48 hpf onwards (last row). The ISH results shown are representative of at least 30 embryos for each stage