Fig. 2.

The roles of lncRNAs in regulating hPSCs pluripotency. a lncRNAs (lncRNA-ROR, lncRNA-HPAT5 and lncRNA-GAS5) act as miRNA sponges to inhibit miRNA activity, promoting pluripotency maintenance of hPSCs. b lncRNA-TUNA interacts with PTBP1, hnRNPK, and NCL1 to regulate NANOG and SOX2 expression through promoter occupancy. c lncRNAs (tsRMST and lncRNA-ES1/ES2/ES3) interact with the PRC2 complex and pluripotency-associated factors (NANOG or SOX2) to inhibit expression of linage-associated genes. d lncRNA-SRA interacts with MLL1 complex, PRC2 complex and the pluripotency-associated factor, NANOG, to promote bivalent domain formation