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tsRMST promotes pluripotency maintenance in hESCs. a The exon order of tsRMST is shown. EX exon. b In hPSCs, interaction of tsRMST with NANOG and PRC2 complex promotes occupancy on inactive genes, such as GATA4, GATA6, PAX6 and WNT5A. c The expression of GATA4 and GATA6 promote endoderm differentiation of hPSCs, while PAX6 promotes ectoderm differentiation. The expression WNT5A further activates epithelial–mesenchymal transition (EMT) to promote endoderm differentiation
