Fig. 5.

Effect of MD54 and MMD54 onto the secretion of cytokines in LPS-stimulated Cells. a Percentage inhibition of levels of LPS-induced secretions of TNF- α, IL-1β, and IL-8 in THP-1 cell lines, respectively. b Percentage inhibition of levels of LPS-induced secretions of IL-8 in HEK-293T transiently transfected with TLR4/MD2/CD14 in the presence of MD54 and MMD54 by ELISA experiments. Each data point is an average of three independent experiments and results are given as the standard error of mean (± SEM); **p < 0.01, Student t test was performed using Graph Pad Prism Version 5.00 vs. LPS