Fig. 7.

Peptide protects mice from LPS challenge. a In vivo estimation of percentage inhibition of TNF-α and IL-6 was done after administration of 10 mg/kg LPS with 5 mg/kg of peptide. Student t test was performed using Graph Pad Prism Version 5.00 vs. MMD54 (**p < 0.01, p = 0.0033). b Survival analysis of the LPS challenged peptide was observed for 5 days. Female Balb/c mice (6–8 week; n = 5) were subjected to LPS challenge with peptide, and survival was determined every 12 h for 120 h after LPS challenge. Survival in MD54 (80%) as compared to LPS and MMD54 (0%) was statistically significant [*p < 0.05, log-rank test (p = 0.0419)]