Fig. 1.

Modulation of full-length ERRγ and ERRγ LBD activities by OHT and BPA. Luciferase activity in cells transfected with a–c full-length ERRγ and an ERE-driven luciferase reporter, or a d Gal4-DBD-ERRγ-LBD fusion protein and a GAL4-driven luciferase reporter. a, d Luciferase activity in U2OS, b in HeLa cells, and c in LS174T cells. Data are expressed as a ratio between firefly luciferase relative light units (RLUs) divided by renilla luciferase RLUs. Tests were performed in duplicate in at least three independent experiments. Data were analyzed for significant differences using Student’s t test (***p < 0.001, **p < 0.01, *p < 0.05). Differences were considered statistically significant at p < 0.05