Table 1.

Protein methylation and their effects on autophagy

HMTs	Targets	Effectors molecules	Impact to autophagy	Tissue/cell	Consequence	References
EZH2	H3K27me3	TSC2, RHOA, DEPTOR, FKBP11, RGS16 and GPI	Inhibition	HeLa, MCF-7, HCT116, LOVO, U2OS, PC3, H719, HT29, and SW620 cell lines	Cell growth retardation	[30]
		LC3B, ATG7	Inhibition	HCT116, LOVO, HCT-15, and DLD-1 cell lines	Cell survival	[33]
	H3K27me3	p14ARF, p16INK4a, p53, pRb, and p21, CDK1, CDK2	Activation	SKOV3/DDP cell line	Cell death	[34]
	H3K27me2/3	ATG5, ATG7	Inhibition	Aortic VSMCs	Cell growth	[36]
EHMT2	H3K9me2	LC3B, WIPI1 and TP53INP2/DOR	Inhibition	Naïve T cell activation	Naïve T cell activation stimulation	[40, 41]
	H3K9me2	Beclin-1	Inhibition	MCF-7, and HS578T cell lines	Poor prognosis	[46]
SMYD3	H3K4me2/me3	BCLAF1	Activation	Bladder cancer	Poor prognosis	[50]
LSD1	H3K4me2	LC3II, p62	Inhibition	HEK293, MEF, HCT116, and U2OS cell lines	Cell proliferation	[52]
CARM1	H3R17me2	TFEB	Activation	MEFs, HeLa, HepG2	Cell survival	[54]
DOT1L	H3K79me2	CD9, MMP9	Inhibition	RAW264.7	Osteoclast dysregulation	[57]
SETD7	ATG16L1 (K151me1)		Inhibition	Cardiomyocytes	Cell death/apoptosis	[63]