Table 1.
MiR-21 target genes and altered pathways in different types of cancer
| Cell line/animal model | Target genes | Pathway | References |
|---|---|---|---|
| Trp53 (–/–) miR-21 (–/–) mice | PTEN | TP53-associated apoptosis and senescence | [27] |
| MCF10A (ER-Src cells) | PTEN | PTEN/Akt/NF-κB | [26] |
| SUM159PT | SESN1 and CAB39L | Invasion and migration | [36] |
| CCR6+ Treg (from murine breast cancer) | PTEN | Cell proliferation | [47] |
| HeLa, HT-3 | RASA1 | EMT and cell migration | [48] |
| DU145 | PTEN | Angiogenesis | [49] |
PTEN phosphatase and tensin homolog, SESN1 sestrin 1, CAB39L calcium binding protein 39 like, RASA1 RAS P21 protein activator 1