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Chemical structure characterization of SI-2 and metabolic stability in human liver microsomes (HLM). (A) 2D NMR spectroscopies of SI-2. (B) Illustration of chemical structure of SI-2. Conjugated imine is the dominant form of SI-2. (C) SI-2 was quickly metabolized in HLM. The half-life of SI-2 in HLM is 3.0 min and the major metabolite is the mono-oxidation on the pyridine ring (Highlighted in red).
