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. Author manuscript; available in PMC: 2024 May 20.
Published in final edited form as: J Med Chem. 2024 Mar 29;67(7):5333–5350. doi: 10.1021/acs.jmedchem.3c01596

Scheme 2. Synthesis Routes of Compounds 6v and 8a-8ba.

Scheme 2.

aReagents and conditions: (i) MeI, NaH, DMF, 0 °C~RT, 2h, 73%; (ii) Hydrazinium hydroxide, Acetic acid, MeOH, RT, overnight, 91%; (iii) (a) 3-methylbenzo[d]thiazole-2(3H)-thione or 3-methylbenzo[d]oxazole-2(3H)-thione, TfOMe, DCM, 0 °C~RT, 2h; (b) 7, TEA, EtOH, 80 °C, 5h, 52~61%, two steps.