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SAR study of pyridine ring
| ||
|---|---|---|
| No. | A ring | IC50 (nM)a |
|
| ||
| 6n |
|
>1000 |
| 6o |
|
>1000 |
| SI-10 (6p) |
|
3.3 |
| 6q |
|
10.7 |
| 6r |
|
>1000 |
| 6s |
|
>1000 |
| 6t |
|
>1000 |
| 6u |
|
>1000 |
The cytotoxicity activities of individual compound to MCF7 cells were determined by the MTT assay. Data are the mean of triplicate determinations.
