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Pharmacokinetic parameters of SI-12 (6c) and SI-10 (6p) in CD-1 mice30
| Compound | Administration | T1/2 (h) | Tmax (h) | Cmax (ng/ml) | AUC0-t (ng*h/ml) | Cl (mL/min/kg) | F |
|---|---|---|---|---|---|---|---|
| SI-12 | IV (1 mg/kg) | 22.5 | 0.033 | 1066 | 737 | 22.0 | -- |
| PO (10 mg/kg) | 14.3 | 0.25 | 217 | 1719 | -- | 24.6% | |
| SI-10 | IV (1 mg/kg) | 3.25 | 0.033 | 552 | 87.6 | 176 | -- |
| PO (10 mg/kg) | 9.09 | 0.25 | 89 | 477 | -- | 54.4% |
