Table 6.

Off-targets interactions of SI-12 (6c) and SI-10 (6p)^a

Compound	Target Class	Assay Name	Assay Target	Mode	RC50 (µM)b
SI-12	GPCR	Calcium Flux	EDNRA	Agonist	6.4c
		Calcium Flux	EDNRA	Antagonist	4.0
		Calcium Flux	HTR2B	Antagonist	4.1
		cAMP	OPRM1	Antagonist	3.1
	Ion Channel	Ion Channel	hERG	Blocker	2.7
	Non-Kinase Enzymes	Enzymatic	COX1	Inhibitor	3.1
		Enzymatic	COX2	Inhibitor	3.0
SI-10	Non-Kinase Enzymes	Enzymatic	COX1	Inhibitor	2.9
		Enzymatic	COX2	Inhibitor	2.4

^aData was obtained by using SafetyScreen panel provided by Eurofins Discovery.

^bRC₅₀ is described as IC₅₀ unless otherwise specified.

^cRC₅₀ is EC₅₀.