Table 3.
Clinicopathological characteristics of 16 marker-null LCC according to their expression profile
| All Patients | Pure-LCC profile |
ADLike-LCC profile |
p-value* | |
|---|---|---|---|---|
| Total | 16 (100) | 11 (100) | 5 (100) | |
| Age | ||||
| Median [range] | 69 [51–84] | 74 [51–84] | 60 [57–68] | 0.023 |
| Gender | ||||
| Female | 1 (6.3) | 1 (9.1) | 0 (0.0) | |
| Male | 15 (93.7) | 10 (90.9) | 5 (100.0) | 1.00 |
| Smoke | ||||
| Never | 1 (6.3) | 1 (9.1) | 0 (0.0) | |
| Ex | 5 (31.3) | 2 (18.2) | 3 (60.0) | |
| Current | 10 (62.5) | 8 (72.7) | 2 (40.0) | 0.35 |
| Mitosis | ||||
| Median [range] | 21.5 [9.0–44.0] | 30.0 [17.0–44.0] | 14.0 [9.0–23.0] | 0.009 |
| Necrosis | ||||
| Absent | 3 (18.8) | 1 (9.1) | 2 (40.0) | |
| Spot | 3 (18.8) | 2 (18.2) | 1 (20.0) | |
| Extensive | 10 (62.5) | 8 (72.7) | 2 (40.0) | 0.46 |
| Stage | ||||
| I | 10 (62.5) | 8 (72.7) | 2 (40.0) | |
| II | 3 (18.8) | 1 (9.1) | 2 (40.0) | |
| III | 2 (12.5) | 1 (9.1) | 1 (20.0) | |
| IV | 1 (6.3) | 1 (9.1) | 0 (0.0) | 0.43 |
| Death event | ||||
| No | 7 (43.8) | 3 (27.3) | 4 (80.0) | |
| Yes | 9 (56.2) | 8 (72.7) | 1 (20.0) | 0.11 |
LCC, large cell carcinoma; ADLike profile
+ LCC with expression profiles similar to those of lung adenocarcinoma
*p-value based on Fisher’s exact for categorical variables and Wilcoxon test for continuous variables
Bold are indicated the statistically significant values