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Menin and p27 immunohistochemistry. A A non-MEN1 parathyroid adenoma control shows retained and strong nuclear MEN1 expression. Nuclear p27 expression is retained in most cells (> 60%). B An exemplary MEN1 parathyroid adenoma with loss of nuclear menin expression (preserved expression in the endothelium; arrowheads). Focal absence of nuclear p27 expression
