Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Apr 5;63(5):669–681. doi: 10.1007/s40262-024-01366-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Fig. 1 — Final model schematic for SG, free SN-38, and tAB. CL_SG clearance of SG, CL_SN38/F apparent clearance of free SN-38, CL_tAB clearance of tAB, IV intravenous, K_REL first-order release rate constant for free SN-38, Q_SG intercompartmental clearance of SG, Q_SN38/F apparent intercompartmental clearance of free SN-38, Q_tAB intercompartmental clearance of tAB, SG sacituzumab govitecan, tAB total antibody, V1_SG central volume of distribution of SG, V2_SG peripheral volume of distribution of SG, V1_SN38/F apparent central volume of distribution of free SN-38, V2_SN38/F apparent peripheral volume of distribution of free SN-38, V1_tAB central volume of distribution of tAB, V2_tAB peripheral volume of distribution of tAB