Fig. 4.

Relationships between continuous (a) and categorical (b) covariates to SG AUC or C_max over the first treatment cycle relative to exposures in a typical patient with the reference covariate value. Gray band shows the 80–125% range. Dots and error bars show predicted exposure and 90% CI, respectively. Categories with less than five patients (three patients with ECOG score of 2, one patient with moderate hepatic impairment, three patients with severe renal impairment, and one patient with missing renal impairment level) were excluded from the plot. ALB albumin, ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, AUC area under the serum concentration-time curve, BILI total bilirubin, CI confidence interval, CLCr creatinine clearance, C_max maximum (peak) serum drug concentration, CPI checkpoint inhibitor, ECOG Eastern Cooperative Oncology Group, HER2 human epidermal growth factor receptor 2, HR hormonal receptor, mBC metastatic breast cancer, mTNBC metastatic triple-negative breast cancer, SG sacituzumab govitecan, Trop-2 trophoblast cell-surface antigen-2, UC urothelial cancer, UGT1A1 uridine 5'-diphospho-glucuronosyltransferase 1A1, ULN upper limit of normal