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. 2024 May 20;9:86. doi: 10.1038/s41541-024-00887-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

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Fig. 2 — Groups of RM were sham-vaccinated or vaccinated with repNP + repGPC. CCHFV-specific IgG to whole virus antigen was measured at indicated day post-prime vaccination (DPV) (a–c). c is data from (b) but individual endpoint titers for each repNP + repGPC animals is shown. d IgG responses to specific recombinant antigens were measured by ELISA. e An IFNγ ELISpot was performed to measure CCHFV-specific responses to peptides spanning the GPC (G1–14) or NP (N1–5). d P values calculated with a two-way ANOVA with Sidak’s multiple comparisons test. ns P > 0.05, ****P < 0.0001. a, b, d Data shown as mean plus standard deviation.