Table 1.
Proportion and incidence of critical values of blood drug concentrations.
| Drug concentration item | Reference range (adult) | Reference range (child) | Critical value | CV and its proportion n (%) |
Number of tests | CV incidence (%) |
|---|---|---|---|---|---|---|
| Vancomycin (trough) (μg/mL) | 10–20 | 5–15 | > 20 | 154 (63.4) | 781 | 19.7 |
| Digoxin (ng/mL) | 0.5–2.0 | 0.8–2.0 | > 2.5 | 37 (15.2) | 738 | 5.0 |
| Tacrolimus (ng/mL) | 5–15 | 5–10 | > 25 | 41(16.9) | 10,791 | 0.4 |
| Cyclosporine (trough) (ng/mL) | 150–600 | 100–200 | > 750 | 2 (0.8) | 1871 | 0.1 |
| Rapamycin (ng/mL) | 5–15 | 5–15 | > 20 | 3 (1.2) | 174 | 1.7 |
| Carbamazepine (μg/mL) | 4–12 | 4–12 | > 20 | 0 | 726 | 0 |
| Phenobarbital (μg/mL) | 15 ~ 40 | 15–40 | > 60 | 1 (0.4) | 172 | 0.6 |
| Phenytoin (μg/mL) | 10–20 | 7–20 | > 40 | 3 (1.2) | 150 | 2 |
| Valproic acid (μg/mL) | 50–100 | 50–100 | > 200 | 0 | 3707 | 0 |
| Total | 241 (100) | 19,110 | 1.3 |