Table 1. Baseline characteristics of study population.
| Characteristics | Total (N = 105) | Wild-type ATTR-CM (n = 44) | Variant ATTR-CM (n = 61) | P value | |
|---|---|---|---|---|---|
| Age, yr | 69.3 ± 13.4 | 81.0 ± 8.8 | 60.9 ± 9.3 | < 0.001 | |
| Male | 69 (65.7) | 30 (68.2) | 39 (63.9) | 0.405 | |
| Body mass index, kg/m2 | 22.3 ± 3.8 | 23.3 ± 3.8 | 21.6 ± 3.8 | 0.027 | |
| Body surface area, /m2 | 1.61 ± 0.21 | 1.61 ± 0.18 | 1.16 ± 0.22 | 0.973 | |
| CAD | 15 (14.3) | 12 (27.3) | 3 (4.9) | 0.002 | |
| Diabetes mellitus | 18 (17.1) | 14 (31.8) | 4 (6.6) | 0.001 | |
| Hypertension | 39 (37.1) | 27 (61.4) | 12 (19.7) | < 0.001 | |
| Stroke | 11 (10.5) | 8 (18.2) | 3 (4.9) | 0.049 | |
| Chronic kidney disease | 24 (22.9) | 17 (38.6) | 7 (11.5) | 0.002 | |
| Dyslipidemia | 28 (58.3) | 18 (40.9) | 10 (16.4) | 0.007 | |
| Duration of symptoms before diagnosis, yr | 2.3 ± 3.3 | 1.6 ± 2.8 | 2.8 ± 3.3 | 0.063 | |
| Diagnostic method | |||||
| Cardiac biopsy | 74 (70.5) | 27 (61.4) | 47 (77.0) | 0.089 | |
| Non cardiac biopsy | 15 (14.3) | 3 (6.8) | 12 (19.7) | 0.090 | |
| Bone scan (non-invasive) | 83 (79.0) | 39 (88.6) | 44 (72.1) | 0.052 | |
| Six minute walk test, m | 400 ± 160 | 378 ± 184 | 462 ± 54 | 0.470 | |
| Systolic blood pressure, mmHg | 109 ± 16 | 114 ± 14 | 105 ± 17 | 0.005 | |
| Diastolic blood pressure, mmHg | 66 ± 11 | 67 ± 10 | 67 ± 12 | 0.763 | |
| NT-proBNP, pg/mL | 1,780 (614–3,452) | 2,695 (989–5,285) | 1,551 (571–2,703) | 0.022 | |
| Troponin T, pg/mL | 52 (27–74) | 71.5 (52.3–91.5) | 41 (25–62) | 0.001 | |
| Estimated GFR, mL/min/1.73 m2 | 77.3 ± 24.6 | 62.4 ± 19.0 | 88.3 ± 22.4 | < 0.001 | |
| ECG | |||||
| Pseudo-infarct ECG | 11 (10.5) | 3 (6.8) | 8 (13.1) | 0.352 | |
| Any blocks | 40 (38.1) | 15 (34.1) | 25 (41.0) | 0.544 | |
| Low/decreased QRS voltage | 15 (14.3) | 5 (11.4) | 10 (16.4) | 0.577 | |
| Atrial fibrillation | 15 (14.3) | 10 (22.7) | 5 (8.2) | 0.048 | |
| Cardiac device | |||||
| Permanent pacemaker | 16 (15.2) | 7 (15.9) | 9 (14.8) | 0.999 | |
| ICD | 3 (2.9) | 3 (4.9) | 0 (0.0) | 0.263 | |
| CRT | 1 (1.0) | 1 (2.3) | 0 (0.0) | 0.419 | |
| Extra-cardiac symptoms | |||||
| Polyneuropathy | 74 (70.5) | 20 (45.5) | 54 (88.5) | < 0.001 | |
| Autonomic neuropathy | 55 (52.4) | 10 (22.7) | 45 (73.8) | < 0.001 | |
| Bilateral CTS | 38 (36.2) | 15 (34.1) | 23 (37.7) | 0.837 | |
| Lumbar spinal stenosis | 28 (26.7) | 13 (29.5) | 15 (24.6) | 0.656 | |
| Rotator cuff tendon tear | 2 (1.9) | 1 (2.3) | 1 (1.6) | 0.999 | |
Values are presented as number (%) for categorical variables and mean ± standard deviation or median (interquartile range) for continuous variables.
ATTR-CM = transthyretin amyloidosis cardiomyopathy, CAD = coronary artery disease, NT-proBNP = N-terminal pro-B-type natriuretic peptide, GFR = glomerular filtration rate, ECG = electrocardiogram, ICD = implantable cardiac defibrillator, CRT = cardiac resynchronization therapy, CTS = carpal tunnel syndrome.