Table 4. Comparison of characteristics between ATTR-CM patient with wall thickness over and less than 12 mm.
| Characteristics | Mean LV wall thickness ≥ 12 mm (n = 86) | Mean LV wall thickness < 12 mm (n = 19) | P value | |
|---|---|---|---|---|
| Age, yr | 68.4 ± 13.4 | 73.6 ± 12.9 | 0.129 | |
| Male | 60 (69.8) | 9 (47.4) | 0.107 | |
| NYHA Fc I/II | 56 (65.1) | 9 (47.4) | 0.193 | |
| NYHA Fc III/IV | 20 (24.7) | 6 (25.0) | 0.999 | |
| Body mass index, kg/m2 | 22.1 ± 3.8 | 23.2 ± 3.7 | 0.262 | |
| Body surface area, m2 | 1.63 ± 0.21 | 1.55 ± 0.19 | 0.128 | |
| Duration from symptom to diagnosis, mon | 30.9 ± 37.7 | 33.0 ± 51.4 | 0.829 | |
| Wild-type ATTR-CM | 34 (39.5) | 10 (41.7) | 0.316 | |
| Variant ATTR-CM | 52 (60.5) | 9 (37.5) | 0.316 | |
| Permanent pacemaker | 15 (17.4) | 1 (5.3) | 0.293 | |
| Systolic blood pressure, mmHg | 107.3 ± 15.1 | 117.6 ± 15.1 | 0.013 | |
| Diastolic blood pressure, mmHg | 66.1 ± 11.5 | 68.9 ± 10.1 | 0.321 | |
| NT-proBNP, pg/mL | 1,993 (798–3,725) | 614 (198–1,704) | 0.003 | |
| Troponin T, pg/mL | 50 (27–78) | 52 (30–63) | 0.523 | |
| ECG | ||||
| Pseudo-infarct ECG | 10 (11.6) | 1 (5.3) | 0.684 | |
| Any blocks | 38 (44.2) | 2 (10.5) | 0.008 | |
| Low/decreased QRS voltage | 12 (14.0) | 3 (15.8) | 0.733 | |
| Atrial fibrillation | 12 (14.0) | 3 (15.8) | 0.733 | |
| Echocardiographic parameters | ||||
| Mean wall thickness, mm | 14.8 ± 2.5 | 10.5 ± 1.3 | < 0.001 | |
| LV mass index, g/m2 | 186.1 ± 52.3 | 116.8 ± 25.7 | < 0.001 | |
| LV ejection fraction, % | 54.8 ± 9.8 | 62.8 ± 10.3 | 0.007 | |
| LA volume index, mL/m2 | 52.5 ± 17.1 | 52.3 ± 28.0 | 0.970 | |
| RV systolic pressure, mmHg | 36.3 ± 12.5 | 38.3 ± 15.9 | 0.580 | |
| Extracardiac symptoms | ||||
| Polyneuropathy | 63 (73.3) | 11 (57.9) | 0.265 | |
| Autonomic neuropathy | 57 (66.3) | 9 (47.4) | 0.188 | |
| Bilateral CTS | 34 (29.5) | 4 (21.1) | 0.188 | |
| Lumbar spinal stenosis | 23 (26.7) | 5 (26.3) | 0.999 | |
| Rotator cuff tendon tear | 2 (2.3) | 0 (0) | 0.999 | |
| Trigger finger | 5 (6.2) | 4 (16.7) | 0.047 | |
Values are presented as number (%) for categorical variables and mean ± standard deviation or median (interquartile range) for continuous variables.
ATTR-CM = transthyretin amyloid cardiomyopathy, LV = left ventricular, NYHA = New York Heart Association, NT-proBNP = N-terminal pro-B-type natriuretic peptide, ECG = electrocardiogram, LA = left atrium, RV = right ventricular, CTS = carpal tunnel syndrome.