Table 1:

EDRN Biospecimen Reference Sets

Reference Set	Type of Specimens	Participants #	Participant Groups
Bladder Cancer	Serum, whole urine, DNA from blood	497	Bladder cancer cases Healthy controls High Risk controls
Breast Cancer	Serum, plasma, buffy coat	832	Pre-diagnosis specimens DCIS cases Invasive cancer cases LCIS cases Benignlater cancer cases Normallater cancer cases Benign Disease Atypia controls Benign Disease non-Atypia controls Normal controls
Cancers in Women Endometrium, Ovary, Breast	Serum, plasma	536	Cases (pooled) Controls (pooled)
Colon Cancer	Serum, plasma, whole urine	150	Cases Adenoma controls Normal controls
Liver Cancer	Serum, plasma	871	Cases Controls
Lung Cancer	Serum, plasma	1,205	Cases Controls High risk controls with CT nodule High risk controls with no CT nodule
Pancreatic Cancer	Serum, plasma	255	Cases Controls
Prostate Cancer	Serum, plasma, buffy coat, RNA, supernatant fluid, whole urine	900	Initial Biopsy w/ Cancer cases Repeat Biopsy w/Cancer cases Confirmed but no biopsy controls Initial Biopsy w/o Cancer controls Repeat Biopsy w/o Cancer controls
Prostate Cancer (retrospective)	Serum	663	Cases Controls