Table 2.

Association between TMAO and coronary atherosclerotic burden in CHD individuals

Log2TMAO µmol/L	N	Model 1				Model 2
		β	t	p value	95% CI	β	t	p value	95% CI
Per 1 µmol/L increase	429	0.287	2.916	0.001	0.173 ~ 0.420	0.179	1.832	0.006	0.096 ~ 0.308
Quantiles
Q1	108	0.022	0.288	0.721	-0.168 ~ 0.283	0.016	0.173	0.819	-0.168 ~ 0.283
Q2	108	0.067	0.684	0.076	-0.079 ~ 0.303	0.059	0.638	0.298	-0.071 ~ 0.219
Q3	106	0.241	2.589	< 0.001	0.112 ~ 0.431	0.229	2.381	< 0.001	0.082 ~ 0.391
Q4	107	0.433	4.607	< 0.001	0.139 ~ 0.728	0.412	4.207	< 0.001	0.104 ~ 0.688

Model 1, unadjusted model; model 2, adjusted for traditional risk factor including age, sex, BMI, SBP, DBP, smoking status, drinking status, self-reported hypertension, self-reported diabetes, self-reported hyperlipidemia, family history of CHD, LDL-C and Hcy; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; CHD, coronary heart disease; LDL-C, low density lipoprotein cholesterol; TMAO, trimethylamine N-oxide; OR, odds ratio; Cl, confidence interval; Q1, the first quantile of log₂TMAO; Q2, the second quantile of log₂TMAO; Q3, the third quantile of log₂TMAO; Q4, the fourth quantile of log₂TMAO