Table 1.
Population characteristics according to MASLD diagnosis
| No MASLD (n = 112) |
MASLD (n = 660) |
P value | |
|---|---|---|---|
| Age, mean ± SD (years) | 57.7 ± 13.8 | 55.2 ± 11.7 | 0.041 |
| Women, n (%) | 47 (42.0) | 257 (38.9) | 0.545 |
| BMI, mean ± SD (kg/m2) | 26.6 ± 3.9 | 30.3 ± 4.9 | < 0.001 |
| Obesity (BMI > 30 kg/m2), n (%) | 23 (20.5) | 315 (47.7) | < 0.001 |
| Metabolic Syndrome, n (%) | 26 (23.2) | 398 (60.3) | < 0.001 |
| Waist circumference, mean ± SD (cm) | 96.1 ± 9.5 | 106.8 ± 11.8 | < 0.001 |
| Glycaemia (mg/dl), mean ± SD | 97.1 ± 27.3 | 105.5 ± 28.5 | 0.004 |
| Diabetes, n (%) | 15 (13.4) | 184 (27.9) | 0.001 |
| Triglycerides, median [IQR] (mg/dl) | 96.0 [78.5-128.3] | 136.0 [103.0-182.8] | < 0.001 |
| HDL-C, mean ± SD (mg/dl) | 56.3 ± 14.3 | 48.2 ± 13.5 | < 0.001 |
| Arterial hypertension, n (%) | 59 (52.7) | 406 (61.5) | 0.077 |
| Systolic BP, median [IQR] (mmHg) | 120.0 [115.0-140.0] | 130.0 [120.0-140.0] | 0.017 |
| Diastolic BP, median [IQR] (mmHg) | 80.0 [70.0–80.0] | 80.0 [70.0–85.0] | 0.007 |
| Previous CVEs, n (%) | 8 (7.1) | 34 (5.2) | 0.390 |
| AST, median [IQR] (UI/l) | 19.0 [16.0–22.0] | 21.0 [17.0–28.0] | < 0.001 |
| ALT, median [IQR] (UI/l) | 17.5 [14.0–23.0] | 27.0 [19.0–42.0] | < 0.001 |
| GGT, median [IQR] (UI/l) | 17.0 [12.0–26.0] | 26.0 [17.0–41.0] | < 0.001 |
| Platelets, mean ± SD (x109/l) | 237.0 ± 64.2 | 238.2 ± 64.3 | 0.858 |
| High Fib-4, n (%) | 2 (1.8) | 15 (2.3) | 0.745 |
| Low Fib-4, n (%) | 88 (78.6) | 539 (81.7) | 0.438 |
| HOMA-IR, median [IQR] | 2.0 [1.4–2.8] | 3.6 [2.6–5.6] | < 0.001 |
| LAP, median [IQR] | 36.6 [27.6–51.2] | 68.7 [47.9–97.4] | < 0.001 |
| VAI, median [IQR] | 1.2 [0.9–1.7] | 2.1 [1.4–3.3] | < 0.001 |
| TyG index, median [IQR] | 4.6 [4.4-4.7] | 4.8 [4.6–4.9] | < 0.001 |
| TG/HDL-C, median [IQR] | 1.7 [1.2–2.5] | 2.9 [2.0-4.4] | < 0.001 |
ALT Alanine aminotransferase, AST Aspartate aminotransferase, BMI Body mass index, CVEs Cardiovascular events, GGT Gamma-glutamyl transferase, HDL-C High-density lipoprotein cholesterol, BP Blood pressure, LAP Lipid accumulation product, VAI Visceral adiposity index, TyG Index Triglyceride-glucose index, TG/HDL-C Triglycerides to HDL-cholesterol ratio, MASLD Metabolic dysfunction-associated steatotic liver disease, IQR Interquartile range, SD Standard deviation