Table 2.

The most 31 important genes related to survival GBM

Gene name	Degree	Stress	Betweenness centrality	Closeness centrality	Radiality	pValue of OS in CGGA (n = 693)	pValue of OS in CGGA (n = 325)	pValue of OS in GEPIA2
IL6	177	307,218	0.0725	0.5371	0.9951	0.57	0.024	0.074
EGFR	166	438,982	0.1248	0.5387	0.9951	0.28	0.11	0.93
STAT3	142	220,886	0.0470	0.5159	0.9947	0.28	0.039	0.39
MMP9	136	186,362	0.0334	0.5051	0.9945	0.095	0.0016	0.11
CD44	129	190,878	0.0429	0.5046	0.9945	0.095	0.16	0.052
FN1	129	204,432	0.0491	0.5074	0.9945	0.02	0.011	0.028
CD4	127	180,146	0.0444	0.4924	0.9942	0.27	0.045	0.24
TGFB1	120	116,178	0.0206	0.4799	0.9942	0.93	0.099	0.42
CXCL8	118	92,292	0.0166	0.4754	0.9938	NR	NR	0.049
CCL2	113	83,784	0.0131	0.4799	0.9939	0.33	0.0039	0.07
IL10	109	78,812	0.0129	0.4758	0.9938	0.99	0.011	0.26
ICAM1	108	76,042	0.0119	0.4795	0.9939	0.08	0.0016	0.14
IL1A	99	54,768	0.0089	0.4603	0.9934	0.36	0.5	0.53
CD274	83	101,018	0.0236	0.4595	0.9934	0.58	0.061	0.38
KDR	75	66,150	0.0127	0.4599	0.9934	0.71	0.0021	0.98
SPP1	75	67,870	0.0148	0.4645	0.9935	0.25	0.46	0.3
ITGB2	73	64,858	0.0129	0.4439	0.9929	0.25	0.11	0.5
CDKN2A	73	101,996	0.0175	0.4645	0.9935	0.006	0.9	0.55
PARP1	72	123,534	0.0234	0.4641	0.9935	0.81	0.69	0.96
MYD88	71	46,916	0.0093	0.4418	0.9929	0.052	0.00041	0.31
AGT	71	76,346	0.0166	0.4516	0.9931	0.29	0.49	0.71
NOTCH1	69	94,738	0.0208	0.4576	0.9933	0.049	0.061	0.6
SERPINE1	68	47,842	0.0082	0.4486	0.9931	0.094	0.15	0.12
TNFRSF1A	67	44,156	0.0100	0.4439	0.9929	0.24	0.12	0.039
CDK1	65	104,270	0.0188	0.4453	0.9930	0.29	0.62	0.45
CAV1	63	109,384	0.0267	0.4497	0.9931	0.26	0.11	0.44
ITGB3	56	66,744	0.0159	0.4428	0.9929	NR	NR	0.24
CDK4	56	74,876	0.0149	0.4435	0.9929	0.54	0.96	0.43
FOXO3	55	59,820	0.0131	0.4519	0.9934	0.79	0.22	0.71
MDM2	52	68,820	0.0158	0.4482	0.9930	0.36	0.029	0.15
PROM1	48	37,454	0.0085	0.4382	0.9928	0.7	0.97	0.86

OS, overall survival; GEPIA2, Gene Expression Profiling Interactive Analysis 2 ; NR, not result