Table 3.
Secondary pharmacokinetic parameter estimates
| Parameter | Primaquine | Carboxy-primaquine | Primaquine carbamoyl-glucuronide |
|---|---|---|---|
| CMAX (ng/mL) | 259 (53.5–764) | 338 (74.3–546) | 1550 (246–7320) |
| TMAX (h) | 0.872 (0.237–1.77) | 4.57 (2.19–18.1) | 1.61 (0.572–1.78) |
| AUC24 (h × ng/mL) | 130 (59.2–491) | 8030 (1490–12,800) | 1240 (242–3100) |
| Half-life (h) | 7.42 (7.04–7.93) | 469 (325–1870) | 17.5 (11.1–28.0) |
Numbers are presented as median (range)
AUC24 is the area under the concentration–time curve up to 24 h, CMAX is the maximum concentration, and TMAX is the time to maximum concentration