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. 2024 May 21;25:126. doi: 10.1186/s13059-024-03278-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Transcription-dependent increased DNA replication rates across long genes. A Average metagene profile for PCNA ChIP-Seq at transcribed genes replicated in the first timepoint clustered by gene length, ± 100 kb around the TSS; bottom panel from TSS to TTS only for genes > 100 kb. B As for A with BrdU-Seq from the first timepoint. C Schematic on how the increase in replication rates across the gene length has been calculated. D Average metagene profile for PCNA ChIP-Seq at genes > 100 kb, separated in four groups based on their transcription levels from [14] Chr-RNA-Seq, TSS ± 100b. E As for A but for genes > 100 kb ranked according to the length of their first intron in long (116 genes) or short introns (116 genes). F As for A but with ChIP-Seq of histone H3