Table 2.

Health outcomes by presence of nausea or vomiting

	All	Presence of nausea			Presence of vomiting			Presence of nausea/vomiting
	Total	Yes	No	p-value	Yes	No	p-value	Yes	No	p-value
All population
N	385	94	291	-	27	358	-	96	289	-
EQ-5D-5L
Utility score	0.79 (0.16)	0.67 (0.16)	0.83 (0.14)	<0.001	0.61 (0.16)	0.81 (0.15)	<0.001	0.67 (0.16)	0.84 (0.14)	<0.001
EQ-5D VAS
VAS score	59.9 (24.4)	43.6 (21.7)	65.1 (22.9)	<0.001	38.1 (22.9)	61.5 (23.7)	<0.001	43.5 (21.7)	65.3 (22.8)	<0.001
WPAI
OWI	37.6% (30.3%)	53.0% (26.6%)	32.6% (29.8%)	<0.001	62.4% (22.2%)	35.2% (30.0%)	<0.001	53.5% (26.4%)	32.2% (29.8%)	<0.001
Absenteeism	6.4% (15.9%)	9.8% (15.7%)	5.3% (15.8%)	0.050	10.2% (15.9%)	6.0% (15.9%)	0.230	9.5% (15.5%)	5.3% (15.9%)	0.067
Presenteeism	35.6% (29.2%)	49.5% (25.0%)	31.0% (29.0%)	<0.001	59.1% (22.1%)	33.3% (28.8%)	<0.001	50.2% (24.9%)	30.6% (28.9%)	<0.001
AI	41.0% (29.5%)	54.0% (25.2%)	36.8% (29.7%)	<0.001	60.7% (23.7%)	39.5% (29.4%)	<0.001	54.3% (25.0%)	36.6% (29.7%)	<0.001
Patients with anemia
N	321	88	233	-	25	296	-	90	231	-
EQ-5D-5L
Utility score	0.77 (0.16)	0.67 (0.16)	0.81 (0.14)	<0.001	0.61 (0.16)	0.78 (0.15)	<0.001	0.66 (0.16)	0.81 (0.14)	<0.001
WPAI
OWI	39.6% (30.0%)	53.9% (26.4%)	34.1% (29.6%)	<0.001	62.3% (22.7%)	37.1% (29.7%)	<0.001	54.4% (26.1%)	33.6% (29.5%)	<0.001
Absenteeism	6.9% (16.6%)	9.9% (16.0%)	5.8% (16.7%)	0.100	10.0% (16.2%)	6.6% (16.6%)	0.360	9.6% (15.8%)	5.9% (16.8%)	0.130
Presenteeism	37.3% (28.9%)	50.5% (24.8%)	32.2% (28.8%)	<0.001	59.1% (22.7%)	34.9% (28.5%)	<0.001	51.1% (24.6%)	31.7% (28.7%)	<0.001
AI	44.1% (28.9%)	55.3% (25.2%)	39.9% (29.2%)	<0.001	61.6% (24.4%)	42.7% (28.8%)	0.002	55.6% (25.0%)	39.7% (29.2%)	<0.001

The numbers in the table represent mean (SD). P-values represent the p-value resulting from the t-test

EQ-5D-5L 5-level EQ-5D version, WPAI Work Productivity and Activity Impairment, OWI Overall Work Impairment, AI Activity Impairment, SD Standard deviation