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. 2024 May 20;22:207. doi: 10.1186/s12916-024-03420-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Antitumor activity and homing ability of TILs in PDX model. A PDX models were established in B-NDG mice from a local cervical cancer recurrence patient which were randomly divided into two groups: group control, which received cryoprotectant, and group TIL, which received homologous TILs generated from the same patient. Tumor volume was measured three times per week, using vernier calipers and calculated using formula A×B^2×0.5, where A and B represented the longest and shortest diameters of the tumor, respectively. Tumor volumes in group TIL were smaller than in group control (p < 0.0001). B The peripheral blood of PDX mice was obtained on day 40 post infusion for flow cytometry. C The tumor samples of PDX mice were obtained on day 40 post infusion for multiplexed immunohistochemistry (mIHC), using the following markers: Ki67, panCK, CD8, and DAPI. The scale bar is 100 µm. PDX, patient-derived xenografts