Table 3.
Hematopoietic stem cell and immune cell subset normal values and characteristics based on age in the bone marrow of healthy donors (absolute numbers and percentages).
| Parameters | Groups | Mean | SEM | Median | SD | Normal Values |
|---|---|---|---|---|---|---|
| HSC (cells/μl) | Child | 255.9 | 13.9 | 245.1 | 85.7 | 117.9–552.4 |
| Adolescence | 176.7 | 12.2 | 173.4 | 48.9 | 97.8–254.4 | |
| Adult | 175.9 | 24.9 | 143.9 | 105.8 | 71.4–430.2 | |
| HSC (%) | Child | 0.32 | 0.01 | 0.30 | 0.08 | 0.18–0.50 |
| Adolescence | 0.26 | 0.01 | 0.24 | 0.07 | 0.16–0.40 | |
| Adult | 0.30 | 0.02 | 0.28 | 0.08 | 0.18–0.43 | |
| Lymphocyte (cells/μl) | Child | 7779 | 520 | 7195 | 3206 | 2659–17109 |
| Adolescence | 5016 | 413 | 4331 | 1653 | 3529–9072 | |
| Adult | 3560 | 331 | 3112 | 1443 | 1356–6165 | |
| Lymphocyte (%) | Child | 11.02 | 0.57 | 11.00 | 3.54 | 5.00–18.00 |
| Adolescence | 7.88 | 0.53 | 7.00 | 2.01 | 5.00–11.00 | |
| Adult | 8.04 | 0.75 | 8.00 | 2.51 | 6.00–15.00 | |
| T cells (cells/μl) | Child | 4568 | 251 | 4767 | 1552 | 1764–8814 |
| Adolescence | 3494 | 350 | 2941 | 1400 | 1406–6557 | |
| Adult | 2612 | 243 | 2462 | 1061 | 1006–4616 | |
| T cells (%) | Child | 60.21 | 1.09 | 60.00 | 6.75 | 39.00–72.00 |
| Adolescence | 70.42 | 2.02 | 71.50 | 7.57 | 54.00–85.00 | |
| Adult | 73.09 | 1.60 | 75.00 | 5.33 | 64.99–83.00 | |
| CD4+ T cells (cells/μl) | Child | 2049 | 115 | 2016 | 713 | 605–3557 |
| Adolescence | 1603 | 171 | 1415 | 663 | 610–2980 | |
| Adult | 1302 | 126 | 1333 | 552 | 460–2712 | |
| CD4+ T cells (%) | Child | 44.81 | 1.28 | 43.00 | 7.94 | 34.00–65.00 |
| Adolescence | 49.50 | 2.14 | 51.00 | 8.00 | 34.00–63.00 | |
| Adult | 52.27 | 1.66 | 52.00 | 5.53 | 43.00–59.00 | |
| CD8+ T cells (cells/μl) | Child | 1842 | 125 | 1763 | 776 | 604–4154 |
| Adolescence | 1370 | 148 | 1167 | 592 | 566–2808 | |
| Adult | 1078 | 105 | 1002 | 457 | 422–1832 | |
| CD8+ T cells (%) | Child | 41.07 | 1.22 | 40.00 | 7.52 | 25.00–55.00 |
| Adolescence | 39.71 | 2.30 | 40.00 | 8.61 | 30.00–56.00 | |
| Adult | 38.45 | 1.21 | 37.00 | 4.03 | 34.00–45.00 | |
| B cells (cells/μl) | Child | 1789 | 156 | 1583 | 950 | 345–4808 |
| Adolescence | 968 | 102 | 976 | 410 | 313–1634 | |
| Adult | 518 | 66 | 430 | 102 | 259–1319 | |
| B cells (%) | Child | 23.73 | 1.00 | 24.00 | 6.18 | 12.00–44.00 |
| Adolescence | 17.92 | 1.76 | 17.00 | 6.59 | 5.00–30.00 | |
| Adult | 14.72 | 1.09 | 15.00 | 3.63 | 9.00–22.00 | |
| NK cells (cells/μl) | Child | 1049 | 93 | 962 | 579 | 211–2619 |
| Adolescence | 505 | 74 | 445 | 296 | 121–1383 | |
| Adult | 391 | 48 | 363 | 210 | 89–973 | |
| NK cells (%) | Child | 13.23 | 0.70 | 13.00 | 4.33 | 3.00–22.00 |
| Adolescence | 9.92 | 0.87 | 10.00 | 3.29 | 3.00–15.00 | |
| Adult | 11.90 | 1.19 | 12.00 | 3.96 | 8.00–20.00 | |
| NKT cells (cells/μl) | Child | 337 | 27 | 333 | 169 | 52–730 |
| Adolescence | 169 | 32 | 266 | 130 | 82–522 | |
| Adult | 27 | 38 | 218 | 169 | 99–618 | |
| NKT cells (%) | Child | 4.68 | 0.42 | 4.00 | 2.62 | 1.00–12.00 |
| Adolescence | 5.85 | 0.61 | 6.50 | 2.31 | 2.00–9.00 | |
| Adult | 7.54 | 0.73 | 7.00 | 2.42 | 5.00–12.00 |