Table 4.
Hematopoietic stem cell and immune cell subset normal values and characteristics based on BMI in the bone marrow of healthy donors (absolute numbers and percentages).
| Parameters | Groups | Mean | SEM | Median | SD | Normal Values |
|---|---|---|---|---|---|---|
| HSC (cells/μl) | Underweight | 251 | 14.92 | 241 | 88.29 | 113–552 |
| Healthy | 191 | 17.81 | 180 | 75.56 | 81–370 | |
| Overweight | 187 | 27.75 | 182 | 87.76 | 76–321 | |
| Obese | 117 | 22.11 | 87 | 49.45 | 71–177 | |
| HSC (%) | Underweight | 0.34 | 0.02 | 0.32 | 0.06 | 0.28–0.47 |
| Healthy | 0.28 | 0.01 | 0.26 | 0.08 | 0.16–0.50 | |
| Overweight | 0.27 | 0.02 | 0.27 | 0.09 | 0.16–0.43 | |
| Obese | 0.32 | 0.02 | 0.32 | 0.08 | 0.20–0.45 | |
| Lymphocyte (cells/μl) | Underweight | 7837 | 535.7 | 7367 | 3169.3 | 2659–17109 |
| Healthy | 4815 | 518.6 | 4022 | 2260.5 | 2562–11294 | |
| Overweight | 4604 | 582.4 | 4558 | 1931.7 | 2230–9072 | |
| Obese | 3154 | 834.7 | 2099 | 1866.5 | 1356–5272 | |
| Lymphocyte (%) | Underweight | 8.68 | 0.67 | 8.75 | 1.90 | 5.00–11.00 |
| Healthy | 9.24 | 0.54 | 9.00 | 2.73 | 5.00–15.00 | |
| Overweight | 8.07 | 0.51 | 8.00 | 1.84 | 6.00–12.00 | |
| Obese | 7.87 | 0.66 | 7.50 | 1.88 | 6.00–10.00 | |
| T cells (cells/μl) | Underweight | 4706 | 255.1 | 4835 | 1509.4 | 1764–8814 |
| Healthy | 3135 | 283.8 | 2742 | 1237.3 | 1788–6253 | |
| Overweight | 3244 | 392.8 | 3317 | 1302.8 | 1681–6077 | |
| Obese | 2256 | 627.1 | 1552 | 1402.1 | 1006–4248 | |
| T cells (%) | Underweight | 60.25 | 1.88 | 59.00 | 5.33 | 53.00–68.00 |
| Healthy | 66.72 | 1.63 | 69.00 | 8.18 | 53.00–85.00 | |
| Overweight | 67.23 | 2.46 | 67.00 | 8.87 | 52.00–83.00 | |
| Obese | 68.50 | 2.23 | 68.00 | 6.32 | 60.00–80.00 | |
| CD4+ T cells (cells/μl) | Underweight | 2117 | 131.4 | 2024 | 777.4 | 605–3768 |
| Healthy | 1572 | 133.8 | 1436 | 583.6 | 831–2849 | |
| Overweight | 1560 | 201.3 | 1464 | 667.9 | 769–2792 | |
| Obese | 1111 | 296.2 | 792 | 662.3 | 460–1857 | |
| CD4+ T cells (%) | Underweight | 43.37 | 1.81 | 43.50 | 5.12 | 35.00–50.00 |
| Healthy | 47.64 | 1.61 | 48.00 | 8.07 | 35.00–63.00 | |
| Overweight | 49.23 | 2.05 | 50.00 | 7.40 | 34.00–59.00 | |
| Obese | 47.25 | 1.67 | 46.50 | 4.74 | 40.00–56.00 | |
| CD8+ T cells (cells/μl) | Underweight | 1908 | 123.1 | 1908 | 728.5 | 797–4154 |
| Healthy | 1201 | 125.3 | 1059 | 546.1 | 604–2757 | |
| Overweight | 1335 | 184.1 | 1396 | 610.3 | 727–2808 | |
| Obese | 944 | 294.7 | 628 | 659.1 | 422–2015 | |
| CD8+ T cells (%) | Underweight | 41.12 | 2.12 | 39.50 | 6.01 | 33.00–52.00 |
| Healthy | 40.32 | 1.35 | 40.00 | 6.77 | 30.00–55.00 | |
| Overweight | 39.84 | 1.72 | 38.00 | 6.20 | 33.00–56.00 | |
| Obese | 41.12 | 1.79 | 42.00 | 5.08 | 32.00–47.00 | |
| B cells (cells/μl) | Underweight | 1747 | 173.3 | 1595 | 1010.4 | 313–4804 |
| Healthy | 985 | 136.5 | 797 | 595.3 | 313–2766 | |
| Overweight | 781 | 138.1 | 557 | 458.2 | 259–1518 | |
| Obese | 591 | 165.2 | 358 | 369.4 | 277–1012 | |
| B cells (%) | Underweight | 23.25 | 1.27 | 23.50 | 3.61 | 18.00–29.00 |
| Healthy | 19.04 | 1.21 | 20.00 | 6.07 | 5.00–29.00 | |
| Overweight | 18.00 | 1.62 | 18.00 | 5.84 | 9.00–28.00 | |
| Obese | 18.62 | 1.79 | 17.00 | 5.06 | 14.00–30.00 | |
| NK cells (cells/μl) | Underweight | 1009 | 90.7 | 876 | 536.9 | 211–2619 |
| Healthy | 619 | 122.4 | 418 | 533.8 | 238–2153 | |
| Overweight | 545 | 106.8 | 475 | 354.4 | 121–1383 | |
| Obese | 252 | 111.1 | 152 | 248.2 | 89–688 | |
| NK cells (%) | Underweight | 15.00 | 1.70 | 15.00 | 4.81 | 8.00–22.00 |
| Healthy | 12.52 | 0.73 | 12.00 | 3.68 | 6.00–22.00 | |
| Overweight | 13.46 | 1.32 | 13.00 | 4.78 | 8.00–20.00 | |
| Obese | 10.00 | 1.30 | 10.00 | 3.70 | 3.00–15.00 | |
| NKT cells (cells/μl) | Underweight | 354 | 26.2 | 362 | 153.1 | 52–730 |
| Healthy | 252 | 31.3 | 220 | 136.5 | 78–624 | |
| Overweight | 354 | 55.9 | 322 | 185.4 | 119–618 | |
| Obese | 114 | 8.4 | 106 | 18.8 | 99–145 | |
| NKT cells (%) | Underweight | 5.12 | 0.76 | 5.50 | 2.16 | 2.00–8.00 |
| Healthy | 5.80 | 0.49 | 5.00 | 2.46 | 2.00–12.00 | |
| Overweight | 6.61 | 0.85 | 6.00 | 3.09 | 2.00–12.00 | |
| Obese | 6.25 | 0.81 | 6.50 | 2.31 | 2.00–9.00 |