Table 2. Primary Reasons for Delay or Discontinuation of Scheduled Cancer Treatment Among Patients With Cancer Diagnosed With SARS-CoV-2 Throughout the COVID-19 Pandemic.
| Reasona | Patients, No./total No. (%) | |||||
|---|---|---|---|---|---|---|
| Total | First wave | Second wave | Third wave | Fourth wave | Fifth wave | |
| Primary reason for the delay or discontinuation of one or more drug-based agents | ||||||
| Progressive or recurrent disease | 52/1584 (3.3) | 10/124 (8.1) | 12/384 (3.1) | 8/405 (2) | 13/498 (2.6) | 9/173 (5.2) |
| Treatment-related toxic effects | 56/1584 (3.5) | 1/124 (0.8) | 13/384 (3.4) | 14/405 (3.5) | 22/498 (4.4) | 6/173 (3.5) |
| Patient’s COVID-19 disease | 1325/1584 (83.6) | 104/124 (83.9) | 312/384 (81.3) | 349/405 (86.2) | 429/498 (86.1) | 131/173 (75.7) |
| Lack of clinical resources | 3/1584 (0.2) | 0 | 2/384 (0.5) | 0 | 1/498 (0.2) | 0 |
| Patient’s choice | 35/1584 (2.2) | 3/124 (2.4) | 16/384 (4.2) | 6/405 (1.5) | 6/498 (1.2) | 4/173 (2.3) |
| Other or unknown | 113/1584 (7.1) | 6/124 (4.8) | 29/384 (7.6) | 28/405 (6.9) | 27/498 (5.4) | 23/173 (13.3) |
| Primary reason for the delay or cancellation of surgery? | ||||||
| Progressive or recurrent disease | 3/133 (2.3) | 0 | 1/33 (3.0) | 0 | 2/43 (4.7) | 0 |
| Patient’s COVID-19 disease | 125/133 (94.0) | 6/6 (100) | 32/33 (97.0) | 31/33 (93.9) | 40/43 (93.0) | 16/18 (88.9) |
| Other or unknown | 5/133 (3.8) | 0 | 0 | 2/33 (6.1) | 1/43 (2.3) | 2/18 (11.1) |
| Primary reason for the delay, alteration, or discontinuation of radiation therapy? | ||||||
| Progressive or recurrent disease | 5/159 (3.1) | 0 | 2/46 (4.3) | 0 | 3/51 (5.9) | 0 |
| Patient’s COVID-19 disease | 133/159 (83.6) | 5/5 (100) | 38/46 (82.6) | 45/50 (90.0) | 41/51 (80.4) | 4/7 (57.1) |
| Patient’s choice | 6/159 (3.8) | 0 | 3/46 (6.5) | 1/50 (2.0) | 0 | 2/7 (28.6) |
| Other or unknown | 15/159 (9.4) | 0 | 3/46 (6.5) | 4/50 (8.0) | 7/51 (13.7) | 1/7 (14.3) |
| Primary reason for the delay or discontinuation of transplant or cellular therapy? | ||||||
| Patient’s COVID-19 disease | 19/23 (82.6) | 0 | 12/15 (80.0) | 3 (100) | 4 (100) | 0 |
| Lack of clinical resources | 1/23 (4.3) | 0 | 1/15 (6.7) | 0 | 0 | 0 |
| Other or unknown | 3/23 (13) | 0 | 2/15 (13.3) | 0 | 0 | 1 (100) |
a
Missing data: drug based (2098 patients); surgery (85 patients); radiation (223 patients); transplant (7 patients).